PDF(Pubmed)
Abstract：
UNASSIGNED: Smoking is the leading cause of death in worldwide and is known as one of the risk factors in the development and pathogenesis of several diseases and most are respiratory and cardiovascular diseases. Secondhand smoke (SHS) exposure is associated with negative health consequences including respiratory tract infection, asthma, and cancer. One of the pathogenesis that has known to cause these diseases is inflammation. Garlic (Allium sativum) is a medicinal herb that contains Allicin and other active constituents that are known to have anti-inflammatory ability by suppressing the expression and production of proinflammatory cytokines that will cause inflammation.
UNASSIGNED: The aim of this study is; to analyze the anti-inflammatory action of Allium sativum ethanol extract to prevent lung damage in the smoker rat model.
UNASSIGNED: This is a case-control study with five groups of rats each group contains of three rats. The five groups were negative control (KN), 10 days (10d) smoker (K1), 20 days (20d) smoker (K2), 20d smoker treated with Allium sativum for 10 days (K3) and 20d smoker treated with Allium sativum for 20 days (K4). After 20 days all animals were sacrificed and histological preparation of lung organs was observed under a microscope with 100 dan 400 times magnification and then captured by photomicrograph for analyzed.
UNASSIGNED: There were improvements in lung structure both in group K3 and K4 . there was a decrease of leucocytes and inflammatory cells infiltration that covered almost all alveolar surface to 10-20% surface area and the dilated alveoli decrease from more than 50% to less than 30% area. The bronchus was clean in both two groups compared to the groups that were not treated with Allium sativum.
UNASSIGNED: This study shows that Allium sativum ethanol extract has the ability to prevent lung damage in the smoker rat model.
UNASSIGNED: The aim of this study is; to analyze the anti-inflammatory action of Allium sativum ethanol extract to prevent lung damage in the smoker rat model.
UNASSIGNED: This is a case-control study with five groups of rats each group contains of three rats. The five groups were negative control (KN), 10 days (10d) smoker (K1), 20 days (20d) smoker (K2), 20d smoker treated with Allium sativum for 10 days (K3) and 20d smoker treated with Allium sativum for 20 days (K4). After 20 days all animals were sacrificed and histological preparation of lung organs was observed under a microscope with 100 dan 400 times magnification and then captured by photomicrograph for analyzed.
UNASSIGNED: There were improvements in lung structure both in group K3 and K4 . there was a decrease of leucocytes and inflammatory cells infiltration that covered almost all alveolar surface to 10-20% surface area and the dilated alveoli decrease from more than 50% to less than 30% area. The bronchus was clean in both two groups compared to the groups that were not treated with Allium sativum.
UNASSIGNED: This study shows that Allium sativum ethanol extract has the ability to prevent lung damage in the smoker rat model.
摘要：
■吸烟是世界范围内死亡的主要原因，被认为是几种疾病发展和发病的危险因素之一，大多数是呼吸系统和心血管疾病。二手烟（SHS）暴露与包括呼吸道感染在内的负面健康后果有关。哮喘,和癌症。已知引起这些疾病的发病机制之一是炎症。大蒜（大蒜）是一种药草，含有大蒜素和其他活性成分，已知通过抑制引起炎症的促炎细胞因子的表达和产生而具有抗炎能力。
■本研究的目的是;分析大蒜乙醇提取物在吸烟大鼠模型中预防肺损伤的抗炎作用。
■这是一项病例对照研究，每组五组大鼠，每组三只大鼠。五组均为阴性对照(KN),10天（10d）吸烟者（K1），20天（20d）吸烟者（K2），20d吸烟者用大蒜处理10天(K3),20d吸烟者用大蒜处理20天(K4)。20天后,处死所有动物,在放大100/400倍的显微镜下观察肺器官的组织学制备,然后通过显微照片捕获用于分析。
■K3组和K4组肺结构均有改善。白细胞和炎性细胞浸润减少，几乎覆盖了所有肺泡表面10-20％的表面积，而扩张的肺泡面积从50％以上减少到30％以下。与未使用大蒜治疗的组相比，两组的支气管都是干净的。
■这项研究表明，大蒜乙醇提取物在吸烟者大鼠模型中具有预防肺损伤的能力。
■本研究的目的是;分析大蒜乙醇提取物在吸烟大鼠模型中预防肺损伤的抗炎作用。
■这是一项病例对照研究，每组五组大鼠，每组三只大鼠。五组均为阴性对照(KN),10天（10d）吸烟者（K1），20天（20d）吸烟者（K2），20d吸烟者用大蒜处理10天(K3),20d吸烟者用大蒜处理20天(K4)。20天后,处死所有动物,在放大100/400倍的显微镜下观察肺器官的组织学制备,然后通过显微照片捕获用于分析。
■K3组和K4组肺结构均有改善。白细胞和炎性细胞浸润减少，几乎覆盖了所有肺泡表面10-20％的表面积，而扩张的肺泡面积从50％以上减少到30％以下。与未使用大蒜治疗的组相比，两组的支气管都是干净的。
■这项研究表明，大蒜乙醇提取物在吸烟者大鼠模型中具有预防肺损伤的能力。
