PDF(Pubmed)
Abstract：
Acute basophilic leukemia (ABL) arising from chronic myeloid leukemia (CML) with abundant mast cells (MCs), coexisting with a complex karyotype is rare. Here, we report an 81-year-old man admitted to our hospital with a history of ABL. He was diagnosed with CML in the chronic phase in January 2018, and Imatinib was used at a daily dose of 400mg. Then, transformation to ABL with abundant MCs in the bone marrow and complex karyotypes including 48,XY, trisomy 8 (+8), isochromosome 17(q10) [i(17)(q10)], and derivative chromosome 22 t(9;22) [der(22)t(9;22)] were discovered simultaneously in January 2022. In conclusion, the increased number of MCs in our case is a reminder that they might play an important role in the prognosis of CML and trigger the development of complex karyotypes. Moreover, this is the first case report of ABL arising from CML with abundant MCs, coexisting with 48,XY, +8, i(17)(q10), and der(22)t(9;22), during Imatinib treatment. Further studies are needed to better characterize this rare condition.
摘要：
由肥大细胞（MC）丰富的慢性粒细胞白血病（CML）引起的急性嗜碱性粒细胞白血病（ABL），与复杂核型共存是罕见的。这里,我们报告了一名81岁的男性患者,他有ABL病史.他于2018年1月在慢性期被诊断为CML，伊马替尼的日剂量为400mg。然后，转化为ABL，骨髓中有丰富的MC和复杂的核型，包括48，XY，三体8(+8),同染色体17(q10)[i(17)(q10)]，和衍生染色体22t（9;22）[der（22）t（9;22）]于2022年1月同时发现。总之,我们病例中MC数量的增加提醒我们,它们可能在CML的预后中起重要作用,并引发复杂核型的发展.此外，这是首例由CML引起的ABL病例报告，与48，XY共存，+8，i(17)(q10)，和der（22）t（9；22），在伊马替尼治疗期间。需要进一步的研究来更好地描述这种罕见的情况。
