Abstract：
Background: The HEcoPerMed consortium developed a methodological guidance for the harmonization and improvement of economic evaluations in personalized medicine. Materials & methods: In three therapeutic areas, health economic models were developed to scrutinize the recommendations of the guidance. Results: Altogether, 20 of the 23 recommendations of the guidance were addressed by the models. Seven recommendations were applied in all studies, six in two of the studies and seven in one of the studies. Recommendations with an essential role on the final conclusions of the analyses were identified in each study. Conclusion: The guidance was found to be best used as a tool to identify and prioritize issues, verify solutions and justify decisions during the economic analysis of personalized interventions.
摘要：
背景：HEcoPerMed联盟开发了一种方法学指导，用于协调和改进个性化医疗中的经济评估。材料与方法：在三个治疗领域，制定了卫生经济模型，以审查指南的建议。结果：总之，这些模型处理了指南的23项建议中的20项。在所有研究中都应用了七项建议，其中两项研究中有6项，其中一项研究中有7项。在每项研究中都确定了对分析的最终结论具有重要作用的建议。结论：发现该指南最好用作识别和确定问题优先级的工具，在个性化干预措施的经济分析过程中验证解决方案并证明决策合理。
