PDF(Pubmed)
Abstract：
UNASSIGNED: To determine the choroidal thickness (mainly subfoveal) using spectral domain optical coherence tomography (SD-OCT) in amblyopic eyes and to compare it with the choroidal thickness (CT) of healthy fellow eyes.
UNASSIGNED: In this prospective study, 140 eyes of 70 patients (aged 5-40 years) with strabismic and anisometropic amblyopia were examined using enhanced depth imaging (EDI) mode in SD-OCT. The CT was measured directly below the fovea and six other locations: 500 μ, 1000 μ, and 1500 μ from fovea in both nasal and temporal quadrants.
UNASSIGNED: The mean age of the patients was 22.5 ± 11.2 years. The mean Best Corrected Visual Acuity (BCVA) in the amblyopic eyes was 0.87 ± 0.47 logMAR and 0 ± 0.02 logMAR in control eyes. The average subfoveal CT was 341.73 ± 60.39 μm in the amblyopic eyes and 314.77 ± 48.12 μm in the fellow eyes. Subgroup analysis showed that the patients with anisometropic amblyopia had a significantly thicker choroid as compared to the fellow healthy eyes (P = 0.00), whereas in strabismic amblyopic eyes, this difference was not significantly significant (P = 0.064).
UNASSIGNED: Significant choroidal thickening was observed in subjects with amblyopia, which may contribute to the amblyopia pathogenesis and this could be used as a diagnostic parameter for amblyopia. These changes were more pronounced in patients with anisometropic amblyopia than strabismic amblyopia.
UNASSIGNED: In this prospective study, 140 eyes of 70 patients (aged 5-40 years) with strabismic and anisometropic amblyopia were examined using enhanced depth imaging (EDI) mode in SD-OCT. The CT was measured directly below the fovea and six other locations: 500 μ, 1000 μ, and 1500 μ from fovea in both nasal and temporal quadrants.
UNASSIGNED: The mean age of the patients was 22.5 ± 11.2 years. The mean Best Corrected Visual Acuity (BCVA) in the amblyopic eyes was 0.87 ± 0.47 logMAR and 0 ± 0.02 logMAR in control eyes. The average subfoveal CT was 341.73 ± 60.39 μm in the amblyopic eyes and 314.77 ± 48.12 μm in the fellow eyes. Subgroup analysis showed that the patients with anisometropic amblyopia had a significantly thicker choroid as compared to the fellow healthy eyes (P = 0.00), whereas in strabismic amblyopic eyes, this difference was not significantly significant (P = 0.064).
UNASSIGNED: Significant choroidal thickening was observed in subjects with amblyopia, which may contribute to the amblyopia pathogenesis and this could be used as a diagnostic parameter for amblyopia. These changes were more pronounced in patients with anisometropic amblyopia than strabismic amblyopia.
摘要：
■使用光谱域光学相干断层扫描（SD-OCT）在弱视眼中确定脉络膜厚度（主要是中央凹下），并将其与健康的同伴眼的脉络膜厚度（CT）进行比较。
■在这项前瞻性研究中，在SD-OCT中使用增强深度成像（EDI）模式检查了70例斜视和屈光参差性弱视患者（5-40岁）的140只眼。CT是在中央凹正下方和其他六个位置测量的：500μ，1000μ,和1500μ从中央凹在鼻和颞部象限。
■患者的平均年龄为22.5±11.2岁。弱视眼的平均最佳矫正视力（BCVA）为0.87±0.47logMAR，对照组为0±0.02logMAR。弱视眼的平均中央凹下CT为341.73±60.39μm，对眼为314.77±48.12μm。亚组分析显示，屈光参差性弱视患者的脉络膜与其他健康眼相比明显更厚（P=0.00），而在斜视弱视眼中，差异无统计学意义(P=0.064).
■在弱视受试者中观察到明显的脉络膜增厚，这可能有助于弱视的发病机制，这可以用作弱视的诊断参数。这些变化在屈光参差性弱视患者中比在斜视性弱视患者中更明显。
■在这项前瞻性研究中，在SD-OCT中使用增强深度成像（EDI）模式检查了70例斜视和屈光参差性弱视患者（5-40岁）的140只眼。CT是在中央凹正下方和其他六个位置测量的：500μ，1000μ,和1500μ从中央凹在鼻和颞部象限。
■患者的平均年龄为22.5±11.2岁。弱视眼的平均最佳矫正视力（BCVA）为0.87±0.47logMAR，对照组为0±0.02logMAR。弱视眼的平均中央凹下CT为341.73±60.39μm，对眼为314.77±48.12μm。亚组分析显示，屈光参差性弱视患者的脉络膜与其他健康眼相比明显更厚（P=0.00），而在斜视弱视眼中，差异无统计学意义(P=0.064).
■在弱视受试者中观察到明显的脉络膜增厚，这可能有助于弱视的发病机制，这可以用作弱视的诊断参数。这些变化在屈光参差性弱视患者中比在斜视性弱视患者中更明显。
