PDF(Pubmed)
Abstract：
Annulus fibrosus (AF) plays a crucial role in the biomechanical loading of intervertebral disc (IVD). AF is difficult to self-heal when the annulus tears develop, because AF has a unique intricate structure and biologic milieu in vivo. Tissue engineering is promising for repairing AF rupture, but construction of suitable mechanical matching devices or scaffolds is still a grand challenge. To deeply know the varied forces involved in the movement of the native annulus is highly beneficial for designing biomimetic scaffolds to recreate the AF function. In this review, we overview six freedom degrees of forces and adhesion strength on AF tissue. Then, we summarize the mechanical modalities to simulate related forces on AF and to assess the characteristics of biomaterials. We finally outline some current advanced techniques to develop mechanically adaptable biomaterials for AF rupture repair.
摘要：
纤维环（AF）在椎间盘（IVD）的生物力学负荷中起着至关重要的作用。当纤维环撕裂发生时,房颤难以自愈,因为房颤在体内具有独特的复杂结构和生物学环境。组织工程有望修复AF破裂，但是建造合适的机械匹配装置或脚手架仍然是一个巨大的挑战。深入了解天然环运动中涉及的各种力对于设计仿生支架以重建AF功能非常有益。在这次审查中,我们概述了AF组织上的六个自由度力和粘附强度。然后，我们总结了模拟房颤相关力和评估生物材料特性的机械模式。最后，我们概述了一些当前的先进技术，以开发用于AF破裂修复的机械适应性生物材料。
