PDF(Pubmed)
Abstract：
Plasma cell, or Zoon\'s, vulvitis (PCV) is a rare inflammatory disorder of the female genital tract. Clinically, it is characterized by erythematous mucosal lesions associated with burning, pruritus, and dyspareunia. Histologically, it is characterized by the thinning of the epithelium with the infiltration of plasma cells in the underlying dermis. There are few case reports describing predominantly vaginal symptoms. Our patient is a 53-year-old postmenopausal female presenting for the gynecologic evaluation of a vaginal pinching sensation and vulvar irritation for three months. On examination, vaginal mucosa was notable for erythematous macules and papules with focal tenderness. Initial evaluation was significant for bacterial vaginosis. This was treated, but it did not improve the patient\'s presenting symptoms. Our preliminary working diagnosis was vulvovaginal atrophy. Biopsies showed plasmacytosis mucosae consistent with Zoon\'s vaginitis. The patient was treated with external clobetasol ointment and hydrocortisone 25 mg vaginal suppositories with improvement in symptoms. Female genital tract lesions engender a range of differential diagnoses, including infectious, immunologic, and malignant causes. In this patient, our initial working diagnosis of genitourinary syndrome of menopause suggested that local hormonal treatment was indicated. However, histological diagnosis directed the use of steroid treatment, ultimately improving the patient\'s symptoms.
摘要：
浆细胞,或者Zoon\'s,外阴炎（PCV）是一种罕见的女性生殖道炎症性疾病。临床上,它的特征是与灼烧相关的红斑粘膜病变，瘙痒,和性交困难.组织学上,它的特征是上皮变薄，浆细胞浸润在下面的真皮中。很少有病例报告主要描述阴道症状。我们的患者是一名53岁的绝经后女性，接受了三个月的阴道捏感和外阴刺激的妇科评估。在检查中，阴道粘膜可见红斑和丘疹伴局部压痛。对细菌性阴道病的初步评估具有重要意义。这是治疗，但它并没有改善患者的症状。我们的初步工作诊断是外阴阴道萎缩。活检显示浆细胞性粘膜与Zoon阴道炎一致。患者接受外用氯倍他索软膏和氢化可的松25mg阴道栓剂治疗，症状得到改善。女性生殖道病变产生一系列的鉴别诊断，包括传染性,免疫学,和恶性原因。在这个病人身上,我们对绝经期泌尿生殖系统综合征的初步诊断提示需要局部激素治疗.然而,组织学诊断指导使用类固醇治疗，最终改善患者的症状。
