PDF(Pubmed)
Abstract：
UNASSIGNED: Congenital melanocytic nevi (CMN) are benign lesions composed of clonal proliferations of melanocytes. Although medium-sized CMN are common and generally remain benign throughout a person\'s lifetime, they may be precursors of melanoma. There is a limited number of studies focused on the risk of melanoma in solitary, medium-sized, congenital melanocytic nevus; therefore, the incidence of malignant transformation and guidelines for treatment are not well established.
UNASSIGNED: Prompted by the limited data, we conducted this study to gather more information about medium-sized CMN, to optimize clinical care. We share our analysis of surgically removed medium-sized CMN.
UNASSIGNED: A total of 10 patients with non-multiple, medium-sized, congenital melanocytic nevus were included in this study. Lesions were removed using surgical procedures.
UNASSIGNED: In most of the cases the reason for excision of the medium-sized CMN was evolution of the lesion or aesthetic considerations reported by the patients. In 2 cases, due to the large size of the lesions, serial excisions were performed, while other CMN were removed surgically using simple excision technique. Eight of 10 medium-sized CMN were histologically described as benign, and 2 cases of malignant transformations were reported.
UNASSIGNED: According to our clinical experience and knowledge, we recommend managing patients on an individual basis, taking into consideration multiple clinical attributes. In our opinion, long-lasting observation is the management of choice, and if there is need of surgery, we recommend total simple or staged excision depending on nevus size.
UNASSIGNED: Prompted by the limited data, we conducted this study to gather more information about medium-sized CMN, to optimize clinical care. We share our analysis of surgically removed medium-sized CMN.
UNASSIGNED: A total of 10 patients with non-multiple, medium-sized, congenital melanocytic nevus were included in this study. Lesions were removed using surgical procedures.
UNASSIGNED: In most of the cases the reason for excision of the medium-sized CMN was evolution of the lesion or aesthetic considerations reported by the patients. In 2 cases, due to the large size of the lesions, serial excisions were performed, while other CMN were removed surgically using simple excision technique. Eight of 10 medium-sized CMN were histologically described as benign, and 2 cases of malignant transformations were reported.
UNASSIGNED: According to our clinical experience and knowledge, we recommend managing patients on an individual basis, taking into consideration multiple clinical attributes. In our opinion, long-lasting observation is the management of choice, and if there is need of surgery, we recommend total simple or staged excision depending on nevus size.
摘要：
■先天性黑素细胞痣（CMN）是由黑素细胞的克隆增殖组成的良性病变。虽然中型CMN很常见，并且在一个人的一生中通常保持良性，它们可能是黑色素瘤的前体。有有限数量的研究集中在单独的黑色素瘤的风险，中型,先天性黑素细胞痣；因此，恶性转化的发生率和治疗指南尚不明确。
■在有限数据的提示下，我们进行了这项研究，以收集有关中型CMN的更多信息，优化临床护理。我们分享我们对手术切除的中型CMN的分析。
■总共10例非多发性的患者，中型,这项研究包括先天性黑素细胞痣。使用外科手术去除病变。
■在大多数情况下，切除中型CMN的原因是病变的演变或患者报告的美学考虑。在两种情况下，由于病变的体积很大,进行了连续切除，而其他CMN则使用简单的切除技术通过手术切除。10个中型CMN中有8个在组织学上被描述为良性，报告2例恶性转化。
■根据我们的临床经验和知识，我们建议以个人为基础管理患者，考虑多种临床属性。在我们看来,长期观察是选择的管理，如果需要手术,我们建议完全简单或分阶段切除取决于痣的大小。
■在有限数据的提示下，我们进行了这项研究，以收集有关中型CMN的更多信息，优化临床护理。我们分享我们对手术切除的中型CMN的分析。
■总共10例非多发性的患者，中型,这项研究包括先天性黑素细胞痣。使用外科手术去除病变。
■在大多数情况下，切除中型CMN的原因是病变的演变或患者报告的美学考虑。在两种情况下，由于病变的体积很大,进行了连续切除，而其他CMN则使用简单的切除技术通过手术切除。10个中型CMN中有8个在组织学上被描述为良性，报告2例恶性转化。
■根据我们的临床经验和知识，我们建议以个人为基础管理患者，考虑多种临床属性。在我们看来,长期观察是选择的管理，如果需要手术,我们建议完全简单或分阶段切除取决于痣的大小。
