PDF(Pubmed)
Abstract：
The dimorphic fungus Blastomyces dermatitidis, is one of the most frequent causes of endemic fungal infections in the United States as well as various other parts of the world. Clinical presentations vary widely, ranging from asymptomatic to disseminated systemic infections. Blastomycosis usually has a predilection for the lungs, but extra pulmonary manifestations are present in 25-40% of cases, involving the skin, bone, genitourinary tract, and CNS. A fungal culture of tissue specimens and fluids is confirmatory. The mainstay of treatment are the azole antifungals, i.e., itraconazole, and for disseminated disease, amphotericin B. We present a case of a young male with pulmonary blastomycosis who presented with a long incubation period. The non-resolving nature of his symptoms prompted further lab and imaging studies, ultimately leading to full and successful recovery.
摘要：
双态真菌皮肤胚芽，是美国以及世界其他地区地方性真菌感染的最常见原因之一。临床表现差异很大，从无症状到播散性全身感染。芽生菌病通常对肺部有好感，但是25-40%的病例存在额外的肺部表现，涉及皮肤，骨头,泌尿生殖道,和CNS。组织标本和液体的真菌培养是确证的。治疗的主要是唑类抗真菌药,即，伊曲康唑,对于传播的疾病，我们介绍了一例年轻男性肺胚真菌病，潜伏期长。他症状的非解决性质促使进一步的实验室和成像研究，最终导致全面和成功的恢复。
