Abstract：
OBJECTIVE: Prognostication is the process of predicting a patient\'s likely outcome from their medical condition, and consists of determining both how well and how long a patient may live. There are few disease-specific prognostic tools to estimate a patient\'s individualized prognosis in terms of symptom burden and mortality. Here we summarize relevant literature on prognosis in four progressive neurologic diseases-dementia, Parkinson\'s disease, amyotrophic lateral sclerosis, and multiple sclerosis-as well as on best practices on communicating prognosis with patients and care partners.
METHODS: We conducted a PubMed search for terms including \"prognosis\", \"mortality\" and \"prognostic indicators\" in addition to specific diseases, and for terms including \"prognosis AND communication\". Only English-language papers were included in this review. The time frame of our literature search was 1965 through March 1, 2023.
UNASSIGNED: There is some literature to help clinicians in predicting disease progression and survival. These include both general factors (e.g., age, medical co-morbidities) and disease-specific factors (e.g., postural instability in Parkinson\'s disease). There is also literature on communication of prognosis in neurologic and non-neurologic disease which demonstrates that many patients and care partners prefer to hear prognosis early after diagnosis and to have prognosis discussed as a roadmap of disease.
CONCLUSIONS: More work is needed to develop tools for individualized prognostication and communication for patients with neurologic disease. While there is limited literature on disease-specific prognostic models, existing literature combined with palliative care approaches may improve prognostic guidance for patients.
METHODS: We conducted a PubMed search for terms including \"prognosis\", \"mortality\" and \"prognostic indicators\" in addition to specific diseases, and for terms including \"prognosis AND communication\". Only English-language papers were included in this review. The time frame of our literature search was 1965 through March 1, 2023.
UNASSIGNED: There is some literature to help clinicians in predicting disease progression and survival. These include both general factors (e.g., age, medical co-morbidities) and disease-specific factors (e.g., postural instability in Parkinson\'s disease). There is also literature on communication of prognosis in neurologic and non-neurologic disease which demonstrates that many patients and care partners prefer to hear prognosis early after diagnosis and to have prognosis discussed as a roadmap of disease.
CONCLUSIONS: More work is needed to develop tools for individualized prognostication and communication for patients with neurologic disease. While there is limited literature on disease-specific prognostic models, existing literature combined with palliative care approaches may improve prognostic guidance for patients.
摘要：
目的：预测是根据患者的医疗状况预测患者可能的结果的过程，包括确定患者的寿命和寿命。在症状负担和死亡率方面，很少有疾病特异性预后工具来估计患者的个体化预后。在这里，我们总结了有关四种进行性神经系统疾病-痴呆的预后的相关文献。帕金森病,肌萎缩侧索硬化，和多发性硬化症-以及与患者和护理伙伴沟通预后的最佳实践。
方法：我们进行了PubMed搜索包括“预后”在内的术语除特定疾病外，“死亡率”和“预后指标”，以及包括“预后和沟通”在内的术语。本评论仅包含英语论文。我们文献检索的时间范围是1965年至2023年3月1日。
■有一些文献可以帮助临床医生预测疾病进展和生存。这些包括两个一般因素(例如，年龄,医学合并症)和疾病特异性因素(例如，帕金森病的姿势不稳定)。也有关于神经系统和非神经系统疾病的预后交流的文献表明，许多患者和护理伙伴更喜欢在诊断后早期听到预后，并将预后作为疾病路线图进行讨论。
结论：需要更多的工作来开发针对神经系统疾病患者的个性化预测和沟通工具。虽然关于疾病特异性预后模型的文献有限，现有文献结合姑息治疗方法可以改善对患者的预后指导.
方法：我们进行了PubMed搜索包括“预后”在内的术语除特定疾病外，“死亡率”和“预后指标”，以及包括“预后和沟通”在内的术语。本评论仅包含英语论文。我们文献检索的时间范围是1965年至2023年3月1日。
■有一些文献可以帮助临床医生预测疾病进展和生存。这些包括两个一般因素(例如，年龄,医学合并症)和疾病特异性因素(例如，帕金森病的姿势不稳定)。也有关于神经系统和非神经系统疾病的预后交流的文献表明，许多患者和护理伙伴更喜欢在诊断后早期听到预后，并将预后作为疾病路线图进行讨论。
结论：需要更多的工作来开发针对神经系统疾病患者的个性化预测和沟通工具。虽然关于疾病特异性预后模型的文献有限，现有文献结合姑息治疗方法可以改善对患者的预后指导.
