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Abstract：
This study investigated the relationship between the structure and mechanical properties of polycaprolactone (PCL) nanocomposites reinforced with baghdadite, a newly introduced bioactive agent. The baghdadite nanoparticles were synthesised using the sol-gel method and incorporated into PCL films using the solvent casting technique. The results showed that adding baghdadite to PCL improved the nanocomposites\' tensile strength and elastic modulus, consistent with the results obtained from the prediction models of mechanical properties. The tensile strength increased from 16 to 21 MPa, and the elastic modulus enhanced from 149 to 194 MPa with fillers compared to test specimens without fillers. The thermal properties of the nanocomposites were also improved, with the degradation temperature increasing from 388 °C to 402 °C when 10% baghdadite was added to PCL. Furthermore, it was found that the nanocomposites containing baghdadite showed an apatite-like layer on their surfaces when exposed to simulated body solution (SBF) for 28 days, especially in the film containing 20% nanoparticles (PB20), which exhibited higher apatite density. The addition of baghdadite nanoparticles into pure PCL also improved the viability of MG63 cells, increasing the viability percentage on day five from 103 in PCL to 136 in PB20. Additionally, PB20 showed a favourable degradation rate in PBS solution, increasing mass loss from 2.63 to 4.08 per cent over four weeks. Overall, this study provides valuable insights into the structure-property relationships of biodegradable-bioactive nanocomposites, particularly those reinforced with new bioactive agents.
摘要：
这项研究研究了巴格达德石增强的聚己内酯（PCL）纳米复合材料的结构与力学性能之间的关系，一种新引入的生物活性剂。Baghdadite纳米颗粒是使用溶胶-凝胶法合成的，并使用溶剂流延技术将其掺入PCL膜中。结果表明，在PCL中加入Baghdadite可以提高纳米复合材料的拉伸强度和弹性模量，与力学性能预测模型的结果一致。抗拉强度从16兆帕增加到21兆帕，与不含填料的试样相比，填料的弹性模量从149提高到194MPa。纳米复合材料的热性能也得到了改善，当在PCL中加入10%的Baghdadite时,降解温度从388°C增加到402°C。此外，研究发现，当暴露于模拟体溶液（SBF）28天时，含有巴格达德石的纳米复合材料在其表面上显示出类似磷灰石的层，特别是在含有20%纳米颗粒（PB20）的薄膜中，表现出更高的磷灰石密度。将Baghdadite纳米颗粒添加到纯PCL中也提高了MG63细胞的活力，将第5天的存活力百分比从PCL中的103增加到PB20中的136。此外,PB20在PBS溶液中表现出良好的降解率,在四周内将质量损失从2.63%增加到4.08%。总的来说,这项研究为生物可降解生物活性纳米复合材料的结构-性质关系提供了有价值的见解，特别是那些用新的生物活性剂增强的。
