PDF(Pubmed)
Abstract：
An efficient method for the synthesis of 2-ethylhexanoic acid has been reported. The method involves the 2-ethylhexanal oxidation using oxygen or air in the presence of N-hydroxyphthalimide in isobutanol as a solvent under mild conditions. A high selectivity of >99% for 2-ethylhexanoic acid was achieved. The influence of catalyst amount, solvent type and quantity, temperature, and reaction time on the product composition was studied. The developed method is in line with the global trends aimed at developing green oxidation processes as well as having potential for implementation in industry due to its high selectivity, cost-effective oxidizing agent, and mild reaction conditions. The use of isobutanol as a solvent is of crucial importance providing an opportunity for potential producers of 2-EHAL from butanal to employ the less valuable alcohol.
摘要：
已经报道了合成2-乙基己酸的有效方法。该方法包括在温和条件下,在N-羟基邻苯二甲酰亚胺的存在下,在作为溶剂的异丁醇中,使用氧气或空气进行2-乙基己醛氧化。实现了对2-乙基己酸的>99%的高选择性。催化剂用量的影响,溶剂类型和数量，温度,研究了反应时间对产物组成的影响。所开发的方法符合旨在开发绿色氧化工艺的全球趋势，并且由于其高选择性，具有在工业中实施的潜力。具有成本效益的氧化剂，和温和的反应条件。使用异丁醇作为溶剂是至关重要的,这为来自丁醛的2-EHAL的潜在生产者提供了使用价值较低的醇的机会。
