PDF(Pubmed)
Abstract：
1,4-Benzothiazines are the main building blocks of the naturally occurring pheomelanin pigments, and their chromophoric properties have been strongly related to the well-known phototoxicity of these pigments, partly responsible for the high incidence of melanoma and other skin cancers in red-haired people. However, some peculiar features of the 1,4-benzothiazine chromophore could be functionally exploited in several sectors. Within this context, in this perspective, an overview of the very recently reported applications of the 1,4-benzothiazine chromophore in pH sensing, filter permeability control, smart packaging, electrochromic device fabrication, bioimaging, photocatalysis, and HPLC detection systems is provided, together with a brief presentation of recently developed synthetic approaches to the 1,4-benzothiazine scaffold, with the aim of emphasizing the still-undervalued multifunctional opportunities offered by this class of compounds.
摘要：
1,4-苯并噻嗪是天然存在的pheomelanin色素的主要组成部分，它们的发色特性与这些颜料众所周知的光毒性密切相关，部分原因是黑素瘤和其他皮肤癌在红发人群中的高发病率。然而,1,4-苯并噻嗪发色团的一些特殊特征可以在几个部门中进行功能开发。在此背景下,从这个角度来看，概述了最近报道的1,4-苯并噻嗪发色团在pH传感中的应用，过滤器渗透率控制，智能包装,电致变色器件制作,生物成像,光催化,和HPLC检测系统提供，以及最近开发的1,4-苯并噻嗪支架的合成方法的简要介绍，目的是强调这类化合物提供的仍然被低估的多功能机会。
