PDF(Pubmed)
Abstract：
In the vertebrate brain, sensory experience plays a crucial role in shaping thalamocortical connections for visual processing. However, it is still not clear how visual experience influences tissue homeostasis and neurogenesis in the developing thalamus. Here, we reported that the majority of SOX2-positive cells in the thalamus are differentiated neurons that receive visual inputs as early as stage 47 Xenopus. Visual deprivation (VD) for 2 days shifts the neurogenic balance toward proliferation at the expense of differentiation, which is accompanied by a reduction in nuclear-accumulated β-catenin in SOX2-positive neurons. The knockdown of β-catenin decreases the expression of SOX2 and increases the number of progenitor cells. Coimmunoprecipitation studies reveal the evolutionary conservation of strong interactions between β-catenin and SOX2. These findings indicate that β-catenin interacts with SOX2 to maintain homeostatic neurogenesis during thalamus development.
摘要：
在脊椎动物的大脑中，感官体验在塑造丘脑皮质连接以进行视觉处理中起着至关重要的作用。然而,目前尚不清楚视觉体验如何影响丘脑发育中的组织稳态和神经发生。这里,我们报道,丘脑中的SOX2阳性细胞大部分是分化的神经元,早在第47期就接受视觉输入.2天的视觉剥夺（VD）使神经源性平衡向增殖转移，但以分化为代价，伴随着SOX2阳性神经元中核积累的β-连环蛋白的减少。β-连环蛋白的敲低降低了SOX2的表达并增加了祖细胞的数量。免疫共沉淀研究揭示了β-连环蛋白和SOX2之间强相互作用的进化保守性。这些发现表明β-catenin与SOX2相互作用以维持丘脑发育过程中的稳态神经发生。
