PDF(Pubmed)
Abstract：
There are very limited methods of relieving dyspnea that are independent of the causative disease. L-menthol olfactory stimulation is reported to be effective for dyspnea during exercise and inspiratory resistance. Therefore, we examined the effects of L-menthol olfactory stimulation on exertional dyspnea during the 6 min walking distance test (6MWT) in patients with chronic breathlessness syndrome. The subjects who consented to the study were divided into two groups. In Group A, the first 6MWT was performed as usual (placebo) while wearing a surgical mask, and the second 6MWT was performed under the L-menthol condition. In Group B, the first 6MWT was performed under the L-menthol condition, and the second 6MWT was performed as a placebo. A total of 16 subjects (70.8 ± 9.5 years) were included in the analysis. As for the effect of reducing dyspnea, a significant difference was observed in Group A patients who underwent the L-menthol condition in the second 6MWT (p = 0.034). In the comparison of the 6 min walking test under the L-menthol condition and the placebo, the modified Borg scale gain was significantly different between the L-menthol condition and the placebo (p = 0.007). Our results suggested that the L-menthol olfactory stimulation reduced dyspnea on exertion in patients with chronic breathlessness syndrome.
摘要：
缓解呼吸困难的方法非常有限，与致病疾病无关。据报道，L-薄荷醇嗅觉刺激对运动过程中的呼吸困难和吸气阻力有效。因此,我们在6分钟步行距离测试(6MWT)期间,研究了L-薄荷醇嗅觉刺激对慢性呼吸困难综合征患者劳力性呼吸困难的影响.同意这项研究的受试者分为两组。A组,第一次6MWT照常（安慰剂）戴着手术口罩，第二个6MWT在L-薄荷醇条件下进行。B组,第一个6MWT是在L-薄荷醇条件下进行的，第二个6MWT作为安慰剂进行。共有16名受试者（70.8±9.5岁）纳入分析。至于减少呼吸困难的效果，在第二次6MWT接受L-薄荷醇治疗的A组患者中观察到显著差异(p=0.034).在L-薄荷醇和安慰剂条件下的6分钟步行试验的比较中，L-薄荷醇和安慰剂组的改良Borg量表增益差异显著(p=0.007).我们的结果表明，L-薄荷醇嗅觉刺激可减少慢性呼吸困难综合征患者劳累时的呼吸困难。
