关键词: Monte Carlo beans health risk assessment heavy metals target hazard quotients

来  源:   DOI:10.3390/foods12173300   PDF(Pubmed)

Abstract:
This study described the distribution of As, Cd, Cr, Hg, and Pb in 692 bean samples from Zhejiang province, southeast China, and estimated the health risk using Monte Carlo simulation. The average levels of As, Cd, Cr, Hg, and Pb were 0.0349, 0.0379, 0.246, 0.0019, and 0.0246 mg kg-1. Correlation analyses showed very strong positive correlations for Cd-Pb in kidney beans and mung beans, Cd-As in black beans, and Pb-As in red beans. The target hazard quotients (THQs) were adopted for non-carcinogenic risk assessment, and THQs at the 50th percentile were all less than 1, indicating that there are no deleterious effects from rice exposure to these elements. When evaluating THQ for multiple elements, the certainty with a hazard index (HI) greater than 1 for children was 12.64%, for teens 11.54%, and for adults 1.01%. The sensitivity analysis reveals that the concentration of Cd in beans and ED (exposure duration) are the main principal factors that contributed to the total risk. The mean carcinogenic risks for children, teens, and adults were all less than 1 × 10-4, indicating no potential carcinogenic risk. Despite that, the routine monitoring of these elements, especially for Cd should be continued.
摘要:
这项研究描述了As的分布,Cd,Cr,Hg,浙江省692个豆类样品中的铅,中国东南部,并使用蒙特卡罗模拟估计健康风险。As的平均水平,Cd,Cr,Hg,Pb分别为0.0349、0.0379、0.246、0.0019和0.0246mgkg-1。相关分析表明,菜豆和绿豆中Cd-Pb的正相关非常强,黑豆中的Cd-As,和红豆中的Pb-As。采用目标危险商数(THQs)进行非致癌风险评估。50百分位数的THQ均小于1,表明水稻暴露于这些元素没有有害影响。当评估多个元素的THQ时,儿童危险指数(HI)大于1的确定性为12.64%,青少年占11.54%,和成人1.01%。敏感性分析表明,豆类中Cd的浓度和ED(暴露持续时间)是造成总风险的主要因素。儿童的平均致癌风险,青少年,和成年人都小于1×10-4,表明没有潜在的致癌风险。尽管如此,这些元素的日常监测,尤其是Cd应该继续。
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