关键词: Apical periodontitis Bacterial persistence Enterococcus faecalis Immune cells Virulence factors

Mesh : Humans Enterococcus faecalis Bacteria Anti-Bacterial Agents / pharmacology therapeutic use Drug-Related Side Effects and Adverse Reactions Periapical Periodontitis

来  源:   DOI:10.1016/j.micpath.2023.106337

Abstract:
Enterococcus faecalis is a commensal bacterium commonly found in the human gastrointestinal tract. However, in individuals with compromised immune systems, the pathogen can lead to severe illness. This opportunistic pathogen is associated with secondary apical diseases and is adept at resisting antibiotics and other forms of treatment because of its numerous virulence factors. Enterococcus faecalis is capable of disrupting the normal functions of immune cells, thereby hindering the body\'s ability to eradicate the infection. However, intensive research is needed in further understanding the adverse immunomodulatory effects of E. faecalis. Potential strategies specific for eradicating E. faecalis have proven beneficial in the treatment of persistent secondary apical periodontitis.
摘要:
粪肠球菌是人类胃肠道中常见的共生细菌。然而,在免疫系统受损的个体中,病原体会导致严重的疾病。这种机会性病原体与继发性根尖疾病相关,并且由于其许多毒力因子而擅长抵抗抗生素和其他形式的治疗。粪肠球菌能够破坏免疫细胞的正常功能,从而阻碍了身体根除感染的能力。然而,需要深入研究以进一步了解粪肠球菌的不良免疫调节作用。根除粪肠球菌的潜在策略已被证明对治疗持续性继发性根尖周炎有益。
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