Abstract:
Ribosome-inactivating proteins (RIPs) are a class of cytotoxic rRNA N-glycosylase, which widely exist in higher plants in different taxonomy, including many traditional Chinese medicinal materials and vegetables and fruits. In this paper, the traditional Chinese medicinal plants containing RIPs protein were sorted out, and their pharmacological effects and clinical applications were analyzed. Since many RIPs in traditional Chinese medicine plants exhibit antiviral and antitumor activities and show great clinical application potential, people\'s interest in these proteins is on the rise. This paper summarizes the possible mechanism of RIPs\'s anti-virus and anti-tumor effects, and discusses its potential problems and risks, laying a foundation for subsequent research on how to exert its anti-virus and anti-tumor effects.
摘要:
核糖体失活蛋白(RIP)是一类细胞毒性rRNAN-糖基化酶,广泛存在于不同分类法的高等植物中,包括许多中药材和蔬菜和水果。在本文中,对含有RIPs蛋白的传统中药植物进行了整理,并对其药理作用和临床应用进行了分析。由于许多RIPs在中药植物中表现出抗病毒和抗肿瘤活性,显示出巨大的临床应用潜力,人们对这些蛋白质的兴趣正在上升。本文综述了RIPs抗病毒和抗肿瘤作用的可能机制,并讨论了其潜在的问题和风险,为后续研究如何发挥其抗病毒和抗肿瘤作用奠定基础。