Abstract：
Whole-genome sequencing (WGS) has resulted in improvements to pathogen characterisation for the rapid investigation and management of disease outbreaks and surveillance. We conducted a systematic review to synthesise the economic evidence of WGS implementation for pathogen identification and surveillance. Of the 2285 unique publications identified through online database searches, 19 studies met the inclusion criteria. The economic evidence to support the broader application of WGS as a front-line pathogen characterisation and surveillance tool is insufficient and of low quality. WGS has been evaluated in various clinical settings, but these evaluations are predominantly investigations of a single pathogen. There are also considerable variations in the evaluation approach. Economic evaluations of costs, effectiveness, and cost-effectiveness are needed to support the implementation of WGS in public health settings.
摘要：
全基因组测序（WGS）已改善了病原体表征，以快速调查和管理疾病暴发和监测。我们进行了系统评价，以综合WGS实施病原体鉴定和监测的经济证据。在通过在线数据库搜索确定的2285种独特出版物中，19项研究符合纳入标准。支持WGS作为一线病原体表征和监视工具的广泛应用的经济证据不足且质量低下。WGS已经在各种临床环境中进行了评估，但这些评估主要是对单一病原体的调查。评估方法也有很大差异。成本的经济评估，有效性,并且需要成本效益来支持在公共卫生环境中实施WGS。
