Abstract：
Sulfa drugs are frequently used to treat infections, particularly in antibiotic resistant people. There are several techniques available to determine sulfa drugs, however, they are laborious operation, reagent consumption, expensive, and need specialized types of equipment. Here, a new, very simple and inexpensive paper-based analytical device described for the determination of five sulfa drugs: sulfacetamide, sulfadiazine, sulfamerazine, sulfamethoxazole, and sulfathiazole in pharmaceutical preparations. The method is a one-step reaction, based on the colorimetric reaction between acid-hydrolyzed sulfa drugs and 4-dimethylaminobenzaldehyde. Using a smartphone, the RGB value of color intensity was used as an analytical signal. The paper-based device displayed linear ranges of 0.10-5.00 µg mL-1, linear correlations ranging from 0.9903 to 0.9972, limits of detection 0.0030 to 0.0082 µg mL-1, and RSD of ≤0.258 under optimal conditions. The suggested approach was applied for determining five sulfa drugs in pharmaceutical formulations. This approach is appropriate for pharmaceutical applications since it is inexpensive, simple to utilize, sensitive, and selective.
摘要：
磺胺类药物经常用于治疗感染，尤其是对抗生素耐药的人。有几种可用的技术来确定磺胺类药物，然而,他们是艰苦的行动，试剂消耗，贵,需要专门类型的设备。这里,一个新的,描述了用于测定五种磺胺类药物的非常简单且廉价的纸质分析设备：磺胺，磺胺嘧啶,磺胺嘧啶,磺胺甲恶唑,和磺胺噻唑在药物制剂中。该方法是一步反应，基于酸水解磺胺类药物与4-二甲基氨基苯甲醛之间的比色反应。使用智能手机，颜色强度的RGB值用作分析信号。在最佳条件下，纸质设备的线性范围为0.10-5.00µgmL-1，线性相关范围为0.9903至0.9972，检出限为0.0030至0.0082µgmL-1，RSD≤0.258。建议的方法用于确定药物制剂中的五种磺胺类药物。这种方法适用于制药应用，因为它便宜，使用简单，敏感,和选择性。
