PDF(Pubmed)
Abstract：
Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is an uncommon benign disorder characterized by the accumulation of activated histiocytes in affected tissues. While RDD typically involves lymph nodes, it may manifest as extranodal involvement. Breast involvement is an exceedingly rare presentation of this condition with <100 reported cases worldwide. This report presents a case of RDD in a 58-year-old male patient who presented with a palpable breast mass. Mammography and ultrasound imaging studies raised concerns for malignancy, prompting a breast biopsy. Histopathological examination revealed S100-positive pale histiocytes exhibiting emperipolesis, consistent with RDD. The management of extranodal RDD is individualized, as no standardized guidelines are currently available. However, surgical excision is recommended for unicentric breast lesions, which was performed in our case, resulting in complete remission. The patient has remained disease-free under surveillance with computed tomography scans. Our case underscores the importance of considering RDD in the differential diagnoses of breast masses and highlights the utility of surgical excision as an effective treatment option, especially for unicentric breast lesions of RDD.
摘要：
Rosai-Dorfman病(RDD),也被称为窦组织细胞增生症伴大量淋巴结病，是一种罕见的良性疾病，其特征是受影响组织中激活的组织细胞积累。虽然RDD通常涉及淋巴结，可能表现为结外受累。乳房受累是这种情况的极为罕见的表现，全世界报告的病例<100例。本报告介绍了一名58岁男性患者的RDD病例，该患者表现出明显的乳房肿块。乳房X线照相术和超声成像研究引起了人们对恶性肿瘤的关注，提示乳房活检。组织病理学检查显示S100阳性的苍白组织细胞表现出全周分泌，与RDD一致。结外RDD的管理是个性化的，因为目前没有标准化指南。然而,手术切除是推荐用于单心乳腺病变，在我们的案例中，导致完全缓解。患者在计算机断层扫描扫描的监测下保持无病。我们的案例强调了在乳腺肿块的鉴别诊断中考虑RDD的重要性，并强调了手术切除作为有效治疗选择的实用性。特别是对于RDD的单心乳腺病变。
