Abstract：
METHODS: A systematic search of PubMed, LIVIVO, and Ovid was conducted up to March 2021. These databases were searched for relevant clinical studies on periodontal treatment success in individuals with Papillon-Lefèvre syndrome (PLS).
METHODS: Clinical studies reporting successful treatment outcomes defined as the loss of four or fewer permanent teeth due to periodontitis and the arrest of periodontitis or probing depths of 5 mm or less in individuals with PLS followed up for ≥24 months were included, and data extracted.
METHODS: Twelve studies reporting on nine PLS patients met the inclusion criteria. The extracted main outcomes in the studies reporting successful periodontal treatment in PLS were as follows: (1) clinical and genetic diagnosis of PLS; (2) age at baseline; (3) initial dental, periodontal parameters, and microbiological assessment, if available; (4) description of disease progression and applied therapies; and (5) outcome and follow-up.
RESULTS: Twelve studies reporting nine individuals were included. The timely extraction of affected or all primary teeth, compliance with oral hygiene instructions, supra- and subgingival debridement within frequent supportive periodontal care intervals, and adjunctive systemic antibiotic therapy in most patients affected a halt in disease progression. Suppression of Aggregatibacter actinomycetemcomitans below detection limits was associated with periodontal stabilization.
CONCLUSIONS: An intensive, multidisciplinary approach with strict compliance may enable the decelerated progression of PLS-associated periodontitis. The early diagnosis of PLS and the suppression of A. actinomycetemcomitans below the detection level might be critical factors for treatment success. It required significant effort and patient compliance. The study emphasized the importance of timely interventions, oral hygiene maintenance, regular professional dental care, and, in some cases, systemic antibiotics.
METHODS: Clinical studies reporting successful treatment outcomes defined as the loss of four or fewer permanent teeth due to periodontitis and the arrest of periodontitis or probing depths of 5 mm or less in individuals with PLS followed up for ≥24 months were included, and data extracted.
METHODS: Twelve studies reporting on nine PLS patients met the inclusion criteria. The extracted main outcomes in the studies reporting successful periodontal treatment in PLS were as follows: (1) clinical and genetic diagnosis of PLS; (2) age at baseline; (3) initial dental, periodontal parameters, and microbiological assessment, if available; (4) description of disease progression and applied therapies; and (5) outcome and follow-up.
RESULTS: Twelve studies reporting nine individuals were included. The timely extraction of affected or all primary teeth, compliance with oral hygiene instructions, supra- and subgingival debridement within frequent supportive periodontal care intervals, and adjunctive systemic antibiotic therapy in most patients affected a halt in disease progression. Suppression of Aggregatibacter actinomycetemcomitans below detection limits was associated with periodontal stabilization.
CONCLUSIONS: An intensive, multidisciplinary approach with strict compliance may enable the decelerated progression of PLS-associated periodontitis. The early diagnosis of PLS and the suppression of A. actinomycetemcomitans below the detection level might be critical factors for treatment success. It required significant effort and patient compliance. The study emphasized the importance of timely interventions, oral hygiene maintenance, regular professional dental care, and, in some cases, systemic antibiotics.
摘要：
方法：对PubMed的系统搜索，LIVIVIVO,和Ovid进行到2021年3月。在这些数据库中搜索了有关Papillon-Lefèvre综合征（PLS）患者牙周治疗成功的相关临床研究。
方法：报告成功治疗结果的临床研究，定义为在PLS患者中，由于牙周炎和牙周炎停止或探查深度小于或等于5mm，随访时间≥24个月，和提取的数据。
方法：12项研究报告9例PLS患者符合纳入标准。在报告PLS成功牙周治疗的研究中，提取的主要结果如下：（1）PLS的临床和遗传诊断；（2）基线年龄；（3）初始牙科，牙周参数，和微生物评估，（4）描述疾病进展和应用的治疗方法；（5）结果和随访。
结果：纳入12项报告9名个体的研究。及时拔除受影响的或所有乳牙，遵守口腔卫生说明，在频繁的支持性牙周护理间隔内进行龈上和龈下清创，大多数患者的辅助全身性抗生素治疗影响了疾病进展的停止。抑制Aggregatibacter放线菌在检测限以下与牙周稳定有关。
结论：密集，具有严格依从性的多学科方法可能会减缓PLS相关牙周炎的进展。PLS的早期诊断和放线菌在检测水平以下的抑制可能是治疗成功的关键因素。这需要大量的努力和患者的依从性。该研究强调了及时干预的重要性，口腔卫生维护,定期专业牙科护理，and,在某些情况下,全身性抗生素。
方法：报告成功治疗结果的临床研究，定义为在PLS患者中，由于牙周炎和牙周炎停止或探查深度小于或等于5mm，随访时间≥24个月，和提取的数据。
方法：12项研究报告9例PLS患者符合纳入标准。在报告PLS成功牙周治疗的研究中，提取的主要结果如下：（1）PLS的临床和遗传诊断；（2）基线年龄；（3）初始牙科，牙周参数，和微生物评估，（4）描述疾病进展和应用的治疗方法；（5）结果和随访。
结果：纳入12项报告9名个体的研究。及时拔除受影响的或所有乳牙，遵守口腔卫生说明，在频繁的支持性牙周护理间隔内进行龈上和龈下清创，大多数患者的辅助全身性抗生素治疗影响了疾病进展的停止。抑制Aggregatibacter放线菌在检测限以下与牙周稳定有关。
结论：密集，具有严格依从性的多学科方法可能会减缓PLS相关牙周炎的进展。PLS的早期诊断和放线菌在检测水平以下的抑制可能是治疗成功的关键因素。这需要大量的努力和患者的依从性。该研究强调了及时干预的重要性，口腔卫生维护,定期专业牙科护理，and,在某些情况下,全身性抗生素。
