Abstract：
This classic discusses the original 1991 publication \'Mesenchymal Stem Cells (MSCs)\' by Dr. Caplan on the emergence of a new therapeutic technology of self-cell repair using MSCs. After the original classic publication, a large number of methods to regenerate injured tissue have been reported. Currently, MSCs are used clinically to repair articular cartilage defects, liver cirrhosis, cerebral infarction, spinal cord injury, graft-versus-host disease and others. As a result, MSCs are considered one of the most important cell sources for regenerative medicine. An MSC has been demonstrated to be a multipotent stem cell in cell culture and was thought to contribute to the regeneration of injured tissue at transplant sites, but recently, the concept of MSCs has changed such that they are now referred to as \"medicinal signaling cells,\" owing to their often indirect effects on tissue repair and regeneration. Regardless of the name, either mesenchymal stem cells or medicinal signaling cells, MSCs will be used to regenerate injured tissue more widely in the near future.
摘要：
本经典讨论了卡普兰博士1991年发表的“间充质干细胞（MSCs）”关于使用MSCs进行自我细胞修复的新治疗技术的出现。在最初的经典出版之后，已经报道了大量再生损伤组织的方法。目前,MSCs在临床上用于修复关节软骨缺损,肝硬化,脑梗塞,脊髓损伤,移植物抗宿主病（GVHD）等。因此,MSCs被认为是再生医学最重要的细胞来源之一。MSC已被证明是细胞培养中的多能干细胞，并被认为有助于移植部位受伤组织的再生。但是最近MSCs的概念发生了变化，它们现在被称为药物信号细胞，由于它们对组织修复和再生的间接作用。不管叫什么名字,间充质干细胞或药物信号细胞，在不久的将来,MSC将更广泛地用于再生损伤组织。
