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Abstract：
Rodents and shrews are major reservoirs of various pathogens that are related to zoonotic infectious diseases. The purpose of this study was to investigate co-infections of zoonotic pathogens in rodents and shrews trapped in four provinces of China. We sampled different rodent and shrew communities within and around human settlements in four provinces of China and characterised several important zoonotic viral, bacterial, and parasitic pathogens by PCR methods and phylogenetic analysis. A total of 864 rodents and shrews belonging to 24 and 13 species from RODENTIA and EULIPOTYPHLA orders were captured, respectively. For viral pathogens, two species of hantavirus (Hantaan orthohantavirus and Caobang orthohantavirus) were identified in 3.47% of rodents and shrews. The overall prevalence of Bartonella spp., Anaplasmataceae, Babesia spp., Leptospira spp., Spotted fever group Rickettsiae, Borrelia spp., and Coxiella burnetii were 31.25%, 8.91%, 4.17%, 3.94%, 3.59%, 3.47%, and 0.58%, respectively. Furthermore, the highest co-infection status of three pathogens was observed among Bartonella spp., Leptospira spp., and Anaplasmataceae with a co-infection rate of 0.46%. Our results suggested that species distribution and co-infections of zoonotic pathogens were prevalent in rodents and shrews, highlighting the necessity of active surveillance for zoonotic pathogens in wild mammals in wider regions.
摘要：
啮齿动物和sh是与人畜共患传染病有关的各种病原体的主要宿主。这项研究的目的是调查中国四个省份被困的啮齿动物和the的人畜共患病原体的共感染。我们在中国四个省的人类住区内部和周围采样了不同的啮齿动物和rew群落，并表征了几种重要的人畜共患病毒，细菌,和寄生虫病原体通过PCR方法和系统发育分析。共捕获了864只啮齿动物和泼妇，属于24种和13种，分别。对于病毒病原体，在3.47％的啮齿动物和sh中发现了两种汉坦病毒（汉坦正坦病毒和草邦正坦病毒）。巴尔通体的总体患病率。,无性子科，巴贝西亚。,钩端螺旋体。,斑点热组立克次体，疏螺旋体属。,伯氏柯西氏菌占31.25%，8.91%，4.17%，3.94%,3.59%,3.47%,和0.58%，分别。此外，在巴尔通菌属中，三种病原体的共感染状态最高。,钩端螺旋体。,与无性子科共感染率为0.46%。我们的结果表明，人畜共患病原体的物种分布和共同感染在啮齿动物和sh中普遍存在，强调了在更广泛地区的野生哺乳动物中积极监测人畜共患病原体的必要性。
