PDF(Pubmed)
Abstract：
UNASSIGNED: Bisphenol A (BPA) is used in large quantities for the production of plastics and is present in various everyday objects. It penetrates living organisms and shows multidirectional adverse influence on many internal organs. For this reason, BPA is often replaced in plastic production by other substances. One of them is bisphenol S (BPS), whose effects on the enteric nervous system (ENS) have not been explained.
UNASSIGNED: Therefore, the present study compares the influence of BPA and BPS on the number of enteric neurons immunoreactive to cocaine-and amphetamine-regulated transcript (CART) peptide located in the ENS of the stomach, jejunum and colon with the use of double immunofluorescence method.
UNASSIGNED: The obtained results have shown that both bisphenols studied induced an increase in the number of CART-positive enteric neurons, and the severity of changes depended on the type of enteric ganglion, the dose of bisphenols and the segment of the digestive tract. The most visible changes were noted in the myenteric ganglia in the colon. Moreover, in the colon, the changes submitted by BPS are more noticeable than those observed after BPA administration. In the stomach and jejunum, bisphenol-induced changes were less visible, and changes caused by BPS were similar or less pronounced than those noted under the impact of BPA, depending on the segment of the gastrointestinal tract and ganglion type studied.
UNASSIGNED: The results show that BPS affects the enteric neurons containing CART in a similar way to BPA, and the BPS impact is even stronger in the colon. Therefore, BPS is not neutral for the gastrointestinal tract and ENS.
UNASSIGNED: Therefore, the present study compares the influence of BPA and BPS on the number of enteric neurons immunoreactive to cocaine-and amphetamine-regulated transcript (CART) peptide located in the ENS of the stomach, jejunum and colon with the use of double immunofluorescence method.
UNASSIGNED: The obtained results have shown that both bisphenols studied induced an increase in the number of CART-positive enteric neurons, and the severity of changes depended on the type of enteric ganglion, the dose of bisphenols and the segment of the digestive tract. The most visible changes were noted in the myenteric ganglia in the colon. Moreover, in the colon, the changes submitted by BPS are more noticeable than those observed after BPA administration. In the stomach and jejunum, bisphenol-induced changes were less visible, and changes caused by BPS were similar or less pronounced than those noted under the impact of BPA, depending on the segment of the gastrointestinal tract and ganglion type studied.
UNASSIGNED: The results show that BPS affects the enteric neurons containing CART in a similar way to BPA, and the BPS impact is even stronger in the colon. Therefore, BPS is not neutral for the gastrointestinal tract and ENS.
摘要：
■双酚A（BPA）大量用于生产塑料，并存在于各种日常用品中。它穿透生物体，并对许多内脏器官表现出多向的不利影响。出于这个原因,BPA在塑料生产中经常被其他物质取代。其中之一是双酚S（BPS），其对肠神经系统（ENS）的影响尚未得到解释。
■因此，本研究比较了BPA和BPS对位于胃ENS中与可卡因和苯丙胺调节转录物（CART）肽免疫反应的肠神经元数量的影响，空肠和结肠用双重免疫荧光法。
■获得的结果表明，所研究的两种双酚均可诱导CART阳性肠神经元数量的增加，变化的严重程度取决于肠神经节的类型，双酚的剂量和消化道的部分。在结肠的肌肠神经节中注意到最明显的变化。此外，在结肠中，BPS提交的变化比BPA给药后观察到的变化更明显。在胃和空肠，双酚诱导的变化不太明显，BPS引起的变化与BPA影响下的变化相似或不太明显，根据所研究的胃肠道节段和神经节类型。
■结果表明，BPS以与BPA相似的方式影响含有CART的肠神经元，结肠中的BPS影响甚至更强。因此,BPS对于胃肠道和ENS不是中性的。
■因此，本研究比较了BPA和BPS对位于胃ENS中与可卡因和苯丙胺调节转录物（CART）肽免疫反应的肠神经元数量的影响，空肠和结肠用双重免疫荧光法。
■获得的结果表明，所研究的两种双酚均可诱导CART阳性肠神经元数量的增加，变化的严重程度取决于肠神经节的类型，双酚的剂量和消化道的部分。在结肠的肌肠神经节中注意到最明显的变化。此外，在结肠中，BPS提交的变化比BPA给药后观察到的变化更明显。在胃和空肠，双酚诱导的变化不太明显，BPS引起的变化与BPA影响下的变化相似或不太明显，根据所研究的胃肠道节段和神经节类型。
■结果表明，BPS以与BPA相似的方式影响含有CART的肠神经元，结肠中的BPS影响甚至更强。因此,BPS对于胃肠道和ENS不是中性的。
