Abstract：
Psoriasis is an inflammatory skin disease affecting over 8 million people in the US and Canada. Approximately, a quarter of psoriasis patients have an inflammatory arthritis termed psoriatic arthritis (PsA). Psoriatic disease encompassing both psoriasis and PsA is regarded as an immune-mediated inflammatory disease, exhibiting both autoimmune and autoinflammatory features. A review of the current literature on the presence and clinical significance of autoantibodies found in psoriatic disease are presented. The frequency of several autoantibodies in psoriasis and PsA patients as well as their clinical significance regarding disease diagnosis, disease activity and treatment response are reviewed. Additionally, the basic principles of antibody assays are presented, and the methods used for each study are analyzed. Despite historically described as a rheumatoid factor negative (seronegative) disease, an array of autoantibodies has been identified in patients with psoriatic disease. This points to an autoimmune component potentially playing a role in psoriatic disease; however, additional evidence is needed to determine the clinical utility of these autoantibodies.
摘要：
牛皮癣是一种炎症性皮肤病，在美国和加拿大影响了800多万人。大约,四分之一的银屑病患者患有炎性关节炎，称为银屑病关节炎（PsA）。包括银屑病和PsA的银屑病疾病被认为是一种免疫介导的炎性疾病。表现出自身免疫和自身炎症特征。介绍了有关银屑病疾病中自身抗体的存在和临床意义的最新文献。银屑病和PsA患者中几种自身抗体的频率及其对疾病诊断的临床意义，回顾了疾病活动和治疗反应。此外,介绍了抗体测定的基本原理，并分析了每项研究使用的方法。尽管历史上被描述为类风湿因子阴性（血清阴性）疾病，已在银屑病患者中鉴定出一系列自身抗体。这表明自身免疫成分可能在银屑病疾病中起作用；然而，需要更多的证据来确定这些自身抗体的临床效用.
