Abstract：
Generalised pustular psoriasis (GPP) and acrodermatitis continua of Hallopeau (ACH) are two rare entities included in the spectrum of pustular psoriasis (PP). Due to the lack of randomised controlled clinical trials and standardized guidelines, their treatment remains a challenge for clinicians. Thus, herein we report our centre experience with the successful use of interleukin (IL)-17 inhibitors in three patients affected by PP. We also provide a brief overview of the current knowledge concerning the role of IL-17 in PP pathogenesis and of the use of IL-17 inhibitors in the treatment of PP. Based on our experience, anti-IL-17 molecules may represent a valuable therapeutical option for patients affected by different PP subtypes.
摘要：
全身性脓疱型银屑病（3GPP）和Hallopeau连续性肢端皮炎（ACH）是脓疱型银屑病（PP）范围内的两种罕见实体。由于缺乏随机对照临床试验和标准化指南，他们的治疗对临床医生来说仍然是一个挑战.因此，本文报道了我们中心在3例PP患者中成功使用白介素(IL)-17抑制剂的经验.我们还简要概述了有关IL-17在PP发病机理中的作用以及IL-17抑制剂在PP治疗中的用途的当前知识。根据我们的经验,对于受不同PP亚型影响的患者,抗IL-17分子可能是一种有价值的治疗选择.
