Abstract：
UNASSIGNED: Background. Sensitization to food and airborne allergens is common in the majority of patients with eosinophilic esophagitis (EoE). Although there is not a direct cause-effect relationship of IgE-mediated allergy with the pathogenesis of EoE, there is a growing evidence that oral desensitization to food and sublingual immunotherapy (SLIT) may induce the development of EoE as an adverse effect. As part of the \'EoE and Allergen Immunotherapy (AIT)\' Task Force funded by the European Academy of Allergy and Clinical Immunology (EAACI), a systematic approach will be followed to review the evidence from the published scientific literature on the development of EoE in children and adults under any type of AIT. Methods. This systematic review will be carried out following the PRISMA statement guidelines. Studies will be assessed for inclusion in the review according to the Population-Interventions-Comparators-Outcomes (PICO) criteria. Results. Expected outcomes will provide evidence on the AIT-EoE development connection. Conclusions. The findings from this review will be used as a reference to provide useful guidelines for physicians treating patients with EoE and/or are practicing AIT.
摘要：
■背景。在大多数嗜酸性粒细胞性食管炎（EoE）患者中，对食物和空气传播的过敏原的敏感性很常见。尽管IgE介导的变态反应与EoE的发病机制没有直接的因果关系,越来越多的证据表明,对食物的口服脱敏和舌下免疫疗法(SLIT)可能会引起EoE的发展,作为一种不良反应.作为由欧洲过敏和临床免疫学会（EAACI）资助的“EoE和过敏原免疫治疗（AIT）”工作组的一部分，我们将采用系统的方法来回顾已发表的科学文献中关于儿童和成人在任何类型的AIT下EoE发展的证据.方法。该系统审查将按照PRISMA声明指南进行。将根据人口-干预-比较-结果（PICO）标准对纳入审查的研究进行评估。结果。预期结果将为AIT-EoE开发联系提供证据。Conclusions.本综述的结果将用作参考，为治疗EoE患者和/或正在进行AIT的医生提供有用的指南。
