Abstract：
Intraperitoneal sporadic tumor is a common and complicated syndrome in cancers, causing a high rate of death, and people find that intraperitoneal chemotherapy (IPC) can treat intraperitoneal sporadic tumors better than intravenous chemotherapy and surgery. However, the effectiveness and side effects of IPC are controversial, and the operation process of IPC is complicated. Herein, the injectable paclitaxel-loaded (PTX-loaded) electrospun short fibers are constructed through a series process of electrospinning, homogenizing, crosslinking, and subsequent polydopamine coating and folate acid (FA) modification. The evenly dispersed short fibers exhibited effective tumor cell killing and good injectable ability, which is convenient to use and greatly improved the complex operation procedure. Mussel-like protein poly-dopamine coating and FA modification endowed short fibers with the ability of targeted adhesion to tumors, and therefore the short fibers further acted as a kind of micro membrane that could release drugs to tumors at close range, maintaining local high drug concentration and prevent paclitaxel killing normal tissues. Thus, the target-adhesive injectable electrospun short fibers are expected to be the potential candidate for cancer treatment, especially the intraperitoneal sporadic tumors, which are hard to treat by surgery or intravenous chemotherapy.
摘要：
腹膜内散发性肿瘤是癌症中常见且复杂的综合征，导致高死亡率，人们发现腹腔化疗（IPC）比静脉化疗和手术治疗腹腔内散发性肿瘤更好。然而,IPC的有效性和副作用是有争议的，IPC的操作过程复杂。在这里，通过一系列静电纺丝工艺构建了可注射的载紫杉醇(PTX)电纺短纤维,均质化，交联，以及随后的聚多巴胺涂层和叶酸（FA）改性。均匀分散的短纤维显示出有效的肿瘤细胞杀伤和良好的注射能力，使用方便，大大提高了复杂的操作程序。贻贝类蛋白聚多巴胺涂层和FA修饰赋予短纤维靶向粘附肿瘤的能力，因此，短纤维进一步充当一种微膜，可以向肿瘤近距离释放药物，维持局部高药物浓度，防止紫杉醇杀死正常组织。因此，靶向粘合剂可注射电纺短纤维有望成为癌症治疗的潜在候选者，尤其是腹膜内散发的肿瘤，很难通过手术或静脉化疗来治疗。
