Abstract：
OBJECTIVE: Attenuating local inflammation of chronic rhinosinusitis with nasal polyps (CRSwNP) after endoscopic sinus surgery (ESS) was crucial. Corticosteroids were generally exploited to ameliorate the postoperative state of CRSwNP. This study aims to verify the efficacy of steroid-eluting stents on the local inflammation of CRSwNP following ESS.
METHODS: 57 CRSwNP were enrolled from September 2021 to April 2022. 30 were with stents, and 27 were without stents after ESS. Eosinophilic cationic protein (ECP), myeloperoxidase (MPO), eosinophil, and neutrophil levels in nasal secretions, as well as visual analog scale (VAS) and modified perioperative sinus endoscopy (POSE) scores, were assessed preoperatively and after 2, 4, 8, and 12 weeks.
RESULTS: All subjects of CRSwNP exhibited reduced results of eosinophil levels, neutrophil levels, nasal obstruction, nasal discharge, loss of smell, and total VAS scores after 12 weeks compared to the preoperative ones (p < 0.05). Compared with control subjects, CRSwNP with stents acquired lower levels of ECP, MPO, loss of smell, total VAS, and POSE scores at four follow-up visits, as well as reduced eosinophil and neutrophil levels in nasal secretions after 12 weeks (p < 0.05). Correlation analysis revealed that postoperative ECP and MPO levels of CRSwNP in nasal secretions correlated strongly with eosinophil and neutrophil levels, respectively, as well as POSE scores (r > 0.6).
CONCLUSIONS: These findings indicated that steroid-eluting stents might be an acclaimed option for CRSwNP in alleviating local inflammation to acquire a superior state after ESS.
METHODS: 57 CRSwNP were enrolled from September 2021 to April 2022. 30 were with stents, and 27 were without stents after ESS. Eosinophilic cationic protein (ECP), myeloperoxidase (MPO), eosinophil, and neutrophil levels in nasal secretions, as well as visual analog scale (VAS) and modified perioperative sinus endoscopy (POSE) scores, were assessed preoperatively and after 2, 4, 8, and 12 weeks.
RESULTS: All subjects of CRSwNP exhibited reduced results of eosinophil levels, neutrophil levels, nasal obstruction, nasal discharge, loss of smell, and total VAS scores after 12 weeks compared to the preoperative ones (p < 0.05). Compared with control subjects, CRSwNP with stents acquired lower levels of ECP, MPO, loss of smell, total VAS, and POSE scores at four follow-up visits, as well as reduced eosinophil and neutrophil levels in nasal secretions after 12 weeks (p < 0.05). Correlation analysis revealed that postoperative ECP and MPO levels of CRSwNP in nasal secretions correlated strongly with eosinophil and neutrophil levels, respectively, as well as POSE scores (r > 0.6).
CONCLUSIONS: These findings indicated that steroid-eluting stents might be an acclaimed option for CRSwNP in alleviating local inflammation to acquire a superior state after ESS.
摘要：
目的：减轻鼻内镜手术（ESS）后慢性鼻-鼻窦炎伴鼻息肉（CRSwNP）的局部炎症至关重要。皮质类固醇通常用于改善CRSwNP的术后状态。本研究旨在验证类固醇洗脱支架对ESS后CRSwNP局部炎症的疗效。
方法：57CRSwNP于2021年9月至2022年4月注册。30个有支架，27人在ESS后没有支架。嗜酸性阳离子蛋白(ECP),髓过氧化物酶(MPO),嗜酸性粒细胞,鼻腔分泌物中的中性粒细胞水平，以及视觉模拟量表（VAS）和改良围手术期鼻窦内镜（POSE）评分，在术前和术后2、4、8和12周进行评估。
结果：所有CRSwNP受试者均表现出嗜酸性粒细胞水平降低的结果，中性粒细胞水平，鼻塞,鼻腔分泌物,失去气味，12周后的总VAS评分与术前相比（p<0.05）。与对照组相比，有支架的CRSwNP获得较低水平的ECP，MPO,失去气味，总VAS,和四次随访时的POSE分数，以及12周后鼻腔分泌物中嗜酸性粒细胞和中性粒细胞水平降低（p<0.05）。相关性分析显示,术后鼻腔分泌物中CRSwNP的ECP和MPO水平与嗜酸性粒细胞和中性粒细胞水平密切相关,分别,以及POSE得分（r>0.6）。
结论：这些结果表明，类固醇洗脱支架可能是CRSwNP在缓解局部炎症以获得ESS后良好状态方面备受好评的选择。
方法：57CRSwNP于2021年9月至2022年4月注册。30个有支架，27人在ESS后没有支架。嗜酸性阳离子蛋白(ECP),髓过氧化物酶(MPO),嗜酸性粒细胞,鼻腔分泌物中的中性粒细胞水平，以及视觉模拟量表（VAS）和改良围手术期鼻窦内镜（POSE）评分，在术前和术后2、4、8和12周进行评估。
结果：所有CRSwNP受试者均表现出嗜酸性粒细胞水平降低的结果，中性粒细胞水平，鼻塞,鼻腔分泌物,失去气味，12周后的总VAS评分与术前相比（p<0.05）。与对照组相比，有支架的CRSwNP获得较低水平的ECP，MPO,失去气味，总VAS,和四次随访时的POSE分数，以及12周后鼻腔分泌物中嗜酸性粒细胞和中性粒细胞水平降低（p<0.05）。相关性分析显示,术后鼻腔分泌物中CRSwNP的ECP和MPO水平与嗜酸性粒细胞和中性粒细胞水平密切相关,分别,以及POSE得分（r>0.6）。
结论：这些结果表明，类固醇洗脱支架可能是CRSwNP在缓解局部炎症以获得ESS后良好状态方面备受好评的选择。
