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Abstract：
Cancer-induced bone pain (CIBP) caused by bone metastasis is one of the most prevalent diseases, and current treatments rely primarily on opioids, which have significant side effects. However, recent developments in pharmaceutical science have identified several new mechanisms for CIBP, including the targeted modification of certain ion channels and receptors. Ion channels are transmembrane proteins, which are situated on biological cell membranes, which facilitate passive transport of inorganic ions across membranes. They are involved in various physiological processes, including transmission of pain signals in the nervous system. In recent years, there has been an increasing interest in the role of ion channels in chronic pain, including CIBP. Therefore, in this review, we summarize the current literature on ion channels, related receptors, and drugs and explore the mechanism of CIBP. Targeting ion channels and regulating their activity might be key to treating pain associated with bone cancer and offer new treatment avenues.
摘要：
骨转移引起的癌性骨痛(CIBP)是最常见的疾病之一,目前的治疗主要依赖于阿片类药物，有明显的副作用。然而,药物科学的最新发展已经确定了CIBP的几种新机制，包括某些离子通道和受体的靶向修饰。离子通道是跨膜蛋白，位于生物细胞膜上，这促进了无机离子跨膜的被动传输。它们参与各种生理过程，包括神经系统中疼痛信号的传递。近年来,人们对离子通道在慢性疼痛中的作用越来越感兴趣，包括CIBP。因此,在这次审查中,我们总结了目前关于离子通道的文献，相关受体，并探讨CIBP的作用机制。靶向离子通道并调节其活性可能是治疗骨癌相关疼痛的关键，并提供新的治疗途径。
