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Abstract：
UNASSIGNED: pernicious anemia is an autoimmune disease characterized by atrophic gastritis due to malabsorption of vitamin B12. Certain oral manifestations, such as Hunter´s glossitis and burning mouth syndrome, may precede the onset of this anemia. The aim of this study is to describe the clinical presentation, para-clinical aspects, the treatment, and the evolution of the pernicious anemia (PA) after treatment.
UNASSIGNED: retrospective study conducted at the Department of Haematology and Internal Medicine B of the Mohammed V Military Training Hospital in Rabat between January 2009 and December 2018. Thirty-four patients were enrolled with vitamin B12 deficiency, non-regenerative macrocytic anemia, a positive anti-intrinsic factor antibody and anti-parietal cell antibody and a histological diagnosis of atrophic gastritis in the presence or not of Helicobacter pylori. The qualitative variables were expressed in numbers and percentages, and the quantitative variables in mean and standard deviation. Multivariate analysis used the Fischer test; it was considered significant for a p < 0.05 value.
UNASSIGNED: thirty-four cases were studied; the population study consists of 56% (n=19) of men and 44% (n=15) of women. The average age was 54.88± 9.14. The clinical manifestations of pernicious anemia are dominated by megaloblastic anemia 85.3% (n=29), followed by digestive 58.8%(n=20) and oral 55.9% (n=19) signs. Neurological manifestations were rarely found in 41% (n=14). Hunter´s glossitis 37% (n=7), stomatodynia 11% (n=2) were the most common oral manifestations accompanying pernicious anemia. The evolution was favorable in 79.4% (n=27) patients under substitution therapy with vitamin B12.
UNASSIGNED: dentists´ involvement in the diagnosis of pernicious anemia is based on changes in oral mucous membranes, which have been reported in 55.9% of all patients. These oral changes may occur in the absence of symptomatic anemia.
UNASSIGNED: retrospective study conducted at the Department of Haematology and Internal Medicine B of the Mohammed V Military Training Hospital in Rabat between January 2009 and December 2018. Thirty-four patients were enrolled with vitamin B12 deficiency, non-regenerative macrocytic anemia, a positive anti-intrinsic factor antibody and anti-parietal cell antibody and a histological diagnosis of atrophic gastritis in the presence or not of Helicobacter pylori. The qualitative variables were expressed in numbers and percentages, and the quantitative variables in mean and standard deviation. Multivariate analysis used the Fischer test; it was considered significant for a p < 0.05 value.
UNASSIGNED: thirty-four cases were studied; the population study consists of 56% (n=19) of men and 44% (n=15) of women. The average age was 54.88± 9.14. The clinical manifestations of pernicious anemia are dominated by megaloblastic anemia 85.3% (n=29), followed by digestive 58.8%(n=20) and oral 55.9% (n=19) signs. Neurological manifestations were rarely found in 41% (n=14). Hunter´s glossitis 37% (n=7), stomatodynia 11% (n=2) were the most common oral manifestations accompanying pernicious anemia. The evolution was favorable in 79.4% (n=27) patients under substitution therapy with vitamin B12.
UNASSIGNED: dentists´ involvement in the diagnosis of pernicious anemia is based on changes in oral mucous membranes, which have been reported in 55.9% of all patients. These oral changes may occur in the absence of symptomatic anemia.
摘要：
■恶性贫血是一种自身免疫性疾病，其特征是由于维生素B12吸收不良引起的萎缩性胃炎。某些口腔表现，比如亨特舌炎和灼口综合征，可能先于这种贫血的发作。本研究的目的是描述临床表现，副临床方面，治疗,以及治疗后恶性贫血（PA）的演变。
■2009年1月至2018年12月在拉巴特的Mohammed五世军事训练医院血液和内科B部门进行的回顾性研究。纳入34例维生素B12缺乏患者，非再生性大细胞性贫血,在幽门螺杆菌存在或不存在的情况下，抗内在因子抗体和抗壁细胞抗体阳性以及萎缩性胃炎的组织学诊断。定性变量以数字和百分比表示，以及均值和标准差的定量变量。多变量分析使用Fischer检验;对于p<0.05值,其被认为是显著的。
■研究了34例；人群研究包括56％（n=19）的男性和44％（n=15）的女性。平均年龄为54.88±9.14。恶性贫血的临床表现以巨幼细胞性贫血为主85.3%(n=29),其次是消化系统58.8%(n=20)和口服55.9%(n=19)。41％（n=14）很少发现神经系统表现。亨特舌炎37%（n=7），11％（n=2）是伴随恶性贫血的最常见的口腔表现。在接受维生素B12替代疗法的79.4％（n=27）患者中，进展良好。
■牙医参与恶性贫血的诊断是基于口腔粘膜的变化，在所有患者的55.9%中已报告。这些口腔变化可能发生在没有症状性贫血的情况下。
■2009年1月至2018年12月在拉巴特的Mohammed五世军事训练医院血液和内科B部门进行的回顾性研究。纳入34例维生素B12缺乏患者，非再生性大细胞性贫血,在幽门螺杆菌存在或不存在的情况下，抗内在因子抗体和抗壁细胞抗体阳性以及萎缩性胃炎的组织学诊断。定性变量以数字和百分比表示，以及均值和标准差的定量变量。多变量分析使用Fischer检验;对于p<0.05值,其被认为是显著的。
■研究了34例；人群研究包括56％（n=19）的男性和44％（n=15）的女性。平均年龄为54.88±9.14。恶性贫血的临床表现以巨幼细胞性贫血为主85.3%(n=29),其次是消化系统58.8%(n=20)和口服55.9%(n=19)。41％（n=14）很少发现神经系统表现。亨特舌炎37%（n=7），11％（n=2）是伴随恶性贫血的最常见的口腔表现。在接受维生素B12替代疗法的79.4％（n=27）患者中，进展良好。
■牙医参与恶性贫血的诊断是基于口腔粘膜的变化，在所有患者的55.9%中已报告。这些口腔变化可能发生在没有症状性贫血的情况下。
