Abstract:
In this project, the possibility of drug delivery application of three anti-Multiple sclerosis (MS) agents (containing diroximel fumarate (DXF), dimethyl fumarate (DMF), and mono methyl fumarate (MMF)) by using some heteroatom decorated graphitic carbonitride (g-C3N4) (as nano-sized carriers) have been systematically investigated. The results of the study have indicated that As-g-C3N4 QD is not a suitable candidate for drug delivery (at least in the cases of DMF, and DXF drugs); while, it would be an accurate semiconductor sensor for selective detection of each mentioned agents. Also, the use of the P-doped as well as pristine g-C3N4 QD could lead to weak electronic signals with relatively same values (in electronvolts). It means that P-g-C3N4, and g-C3N4 QDs are not good sensors for detection of each of the three considered drugs. However, those two sorbents would be suitable carriers for delivering of all three mentioned pharmaceuticals.
摘要:
在这个项目中,三种抗多发性硬化(MS)药物的药物递送应用的可能性(含有富马酸二罗肟(DXF),富马酸二甲酯(DMF),和富马酸单甲酯(MMF))通过使用一些杂原子修饰的石墨碳氮化物(g-C3N4)(作为纳米级载体)进行了系统研究。研究结果表明,As-g-C3N4QD不是药物递送的合适候选者(至少在DMF的情况下,和DXF药物);而,这将是一种精确的半导体传感器,用于选择性检测每种提到的试剂。此外,P掺杂以及原始g-C3N4QD的使用可能导致具有相对相同值(以电子伏特为单位)的弱电子信号。这意味着P-g-C3N4和g-C3N4QD不是用于检测三种考虑的药物中的每一种的良好传感器。然而,这两种吸附剂将是用于递送所有三种所述药物的合适载体。