Abstract：
BACKGROUND: and Sex and cognitive profile may be related to the laterality of motor symptoms in idiopathic Parkinson\'s disease.
BACKGROUND: Parkinson\'s disease (PD) is well recognised as an inherently asymmetric disease with unilateral onset of motor symptoms. The laterality of motor symptoms may be linked to sex, clinical and demographic variables, and neuropsychological disorders. However, the available data are inconsistent. This study aimed to explore the potential association between the laterality of motor symptoms and clinical and demographic variables and deficits in specific cognitive domains.
METHODS: We retrospectively recruited 97 participants with idiopathic PD without dementia; 60 presented motor symptoms on the left side and 37 on the right side. Both groups were comparable in terms of age, age at disease onset, disease duration, and severity of the neurological deficits according to the Unified Parkinson\'s Disease Rating Scale and the Hoehn and Yahr scale.
RESULTS: Participants with left-side motor symptoms scored lower on the Schwab and England Activities of Daily Living scale. Our sample included more men than women (67% vs. 33%). Both sexes were not equally represented in the 2 groups: there were significantly more men than women in the group of patients with left-side motor symptoms (77% vs. 23%), whereas the percentages of men and women in the group of patients with right-side motor symptoms were similar (51% vs. 49%). Both groups performed similarly in all neuropsychological tasks, but women, independently of laterality, performed better than men in the naming task.
CONCLUSIONS: We found a clear prevalence of men in the group of patients with left-side motor symptoms; this group also scored lower on the Schwab and England Scale. Female sex was predictive of better performance in the naming task. Sex should always be considered in disorders that cause asymmetric involvement of the brain, such as PD.
BACKGROUND: Parkinson\'s disease (PD) is well recognised as an inherently asymmetric disease with unilateral onset of motor symptoms. The laterality of motor symptoms may be linked to sex, clinical and demographic variables, and neuropsychological disorders. However, the available data are inconsistent. This study aimed to explore the potential association between the laterality of motor symptoms and clinical and demographic variables and deficits in specific cognitive domains.
METHODS: We retrospectively recruited 97 participants with idiopathic PD without dementia; 60 presented motor symptoms on the left side and 37 on the right side. Both groups were comparable in terms of age, age at disease onset, disease duration, and severity of the neurological deficits according to the Unified Parkinson\'s Disease Rating Scale and the Hoehn and Yahr scale.
RESULTS: Participants with left-side motor symptoms scored lower on the Schwab and England Activities of Daily Living scale. Our sample included more men than women (67% vs. 33%). Both sexes were not equally represented in the 2 groups: there were significantly more men than women in the group of patients with left-side motor symptoms (77% vs. 23%), whereas the percentages of men and women in the group of patients with right-side motor symptoms were similar (51% vs. 49%). Both groups performed similarly in all neuropsychological tasks, but women, independently of laterality, performed better than men in the naming task.
CONCLUSIONS: We found a clear prevalence of men in the group of patients with left-side motor symptoms; this group also scored lower on the Schwab and England Scale. Female sex was predictive of better performance in the naming task. Sex should always be considered in disorders that cause asymmetric involvement of the brain, such as PD.
摘要：
背景：和性别和认知特征可能与特发性帕金森病运动症状的偏侧性有关。
背景：帕金森病（PD）被公认为是一种固有的不对称疾病，具有运动症状的单侧发作。运动症状的偏侧性可能与性别有关，临床和人口统计学变量，和神经心理障碍。然而,可用数据不一致。本研究旨在探讨运动症状的偏侧性与特定认知领域的临床和人口统计学变量和缺陷之间的潜在关联。
方法：我们回顾性地招募了97名患有特发性PD但没有痴呆的参与者；左侧有60人出现运动症状，右侧有37人出现运动症状。两组在年龄方面具有可比性，发病年龄,疾病持续时间,根据统一帕金森病评定量表和Hoehn和Yahr量表，神经功能缺损的严重程度。
结果：具有左侧运动症状的参与者在施瓦布和英格兰日常生活活动量表上得分较低。我们的样本中男性多于女性(67%与33%）。两组中男女的比例不相等：左侧运动症状患者组中男性明显多于女性（77％vs.23%），而右侧运动症状患者组中男性和女性的百分比相似(51%vs.49%)。两组在所有神经心理任务中表现相似，但是女人,独立于横向，在命名任务中表现优于男性。
结论：我们发现在左侧运动症状患者组中男性的患病率明显；该组在施瓦布和英格兰量表上得分也较低。女性可以预测在命名任务中的表现更好。在导致大脑不对称受累的疾病中，应始终考虑性别，比如PD。
背景：帕金森病（PD）被公认为是一种固有的不对称疾病，具有运动症状的单侧发作。运动症状的偏侧性可能与性别有关，临床和人口统计学变量，和神经心理障碍。然而,可用数据不一致。本研究旨在探讨运动症状的偏侧性与特定认知领域的临床和人口统计学变量和缺陷之间的潜在关联。
方法：我们回顾性地招募了97名患有特发性PD但没有痴呆的参与者；左侧有60人出现运动症状，右侧有37人出现运动症状。两组在年龄方面具有可比性，发病年龄,疾病持续时间,根据统一帕金森病评定量表和Hoehn和Yahr量表，神经功能缺损的严重程度。
结果：具有左侧运动症状的参与者在施瓦布和英格兰日常生活活动量表上得分较低。我们的样本中男性多于女性(67%与33%）。两组中男女的比例不相等：左侧运动症状患者组中男性明显多于女性（77％vs.23%），而右侧运动症状患者组中男性和女性的百分比相似(51%vs.49%)。两组在所有神经心理任务中表现相似，但是女人,独立于横向，在命名任务中表现优于男性。
结论：我们发现在左侧运动症状患者组中男性的患病率明显；该组在施瓦布和英格兰量表上得分也较低。女性可以预测在命名任务中的表现更好。在导致大脑不对称受累的疾病中，应始终考虑性别，比如PD。
