Abstract：
OBJECTIVE: In auditory brainstem implant (ABI) surgery, array placement may be optimized by electrophysiological information of adequate brainstem activation gained from electrically evoked auditory brainstem responses (EABR). This study aims 1) to characterize in detail the EABR from ABI implantation, 2) to introduce an EABR Classification Scheme, and 3) to analyze data for their correlation with individual patients\' findings.
METHODS: Out of a continuous series of 54 patients who received an ABI between 2005 and 2019, 23 Neurofibromatosis Type 2 patients with complete documentation of 154 recordings were selected for offline analysis and for development and evaluation of a new EABR Classification Scheme comprising Class A: three vertex positive peaks, Class B:two peaks, Class C: a combination of one peak and a second melted double peak, Class D: one sole vertex positive peak and Class E: no peaks.
RESULTS: All 23 subjects showed EABR at final ABI position and experienced auditory sensations at first activation. The most frequent morphology consisted of two peaks, Classes B and C. Identified mean latencies were for P1 0.42 ms (±0.095), P2 1.42 ms (±0.244) and P3 2.41 ms (±0.329). Peak latencies correlated positively with tumor extensions (p < 0.005).
CONCLUSIONS: This study provides clear instructions on optimal EABR performance and evaluation.
CONCLUSIONS: The new EABR Classification Scheme relies on a fast \"online\" identification of vertex positive peaks at the estimated post-artifact phase. The variability in EABR morphology provides an individual snapshot of the actual structural and functional status of the brainstem.
METHODS: Out of a continuous series of 54 patients who received an ABI between 2005 and 2019, 23 Neurofibromatosis Type 2 patients with complete documentation of 154 recordings were selected for offline analysis and for development and evaluation of a new EABR Classification Scheme comprising Class A: three vertex positive peaks, Class B:two peaks, Class C: a combination of one peak and a second melted double peak, Class D: one sole vertex positive peak and Class E: no peaks.
RESULTS: All 23 subjects showed EABR at final ABI position and experienced auditory sensations at first activation. The most frequent morphology consisted of two peaks, Classes B and C. Identified mean latencies were for P1 0.42 ms (±0.095), P2 1.42 ms (±0.244) and P3 2.41 ms (±0.329). Peak latencies correlated positively with tumor extensions (p < 0.005).
CONCLUSIONS: This study provides clear instructions on optimal EABR performance and evaluation.
CONCLUSIONS: The new EABR Classification Scheme relies on a fast \"online\" identification of vertex positive peaks at the estimated post-artifact phase. The variability in EABR morphology provides an individual snapshot of the actual structural and functional status of the brainstem.
摘要：
目的：在听觉脑干植入（ABI）手术中，可以通过电诱发听觉脑干反应（EABR）获得的足够脑干激活的电生理信息来优化阵列放置。本研究旨在1）详细表征ABI植入的EABR，2)引入EABR分类方案，和3)分析数据与个体患者发现的相关性。
方法：在2005年至2019年期间接受ABI的54例连续系列患者中，选择23例2型神经纤维瘤病患者进行离线分析，并开发和评估包含A类的新EABR分类方案：三个顶点阳性峰，乙级:两峰,C类：一个峰和第二个熔化的双峰的组合，D类:一个单一顶点正峰,E类:无峰。
结果：所有23名受试者在最终ABI位置均显示EABR，并在首次激活时经历听觉感觉。最常见的形态由两个峰组成，B类和C类。确定的平均延迟为P10.42ms(±0.095)，P21.42ms(±0.244)和P32.41ms(±0.329)。峰值潜伏期与肿瘤扩展呈正相关(p<0.005)。
结论：本研究提供了有关最佳EABR性能和评估的明确说明。
结论：新的EABR分类方案依赖于在估计的后伪影阶段快速“在线”识别顶点正峰。EABR形态的可变性提供了脑干实际结构和功能状态的个体快照。
方法：在2005年至2019年期间接受ABI的54例连续系列患者中，选择23例2型神经纤维瘤病患者进行离线分析，并开发和评估包含A类的新EABR分类方案：三个顶点阳性峰，乙级:两峰,C类：一个峰和第二个熔化的双峰的组合，D类:一个单一顶点正峰,E类:无峰。
结果：所有23名受试者在最终ABI位置均显示EABR，并在首次激活时经历听觉感觉。最常见的形态由两个峰组成，B类和C类。确定的平均延迟为P10.42ms(±0.095)，P21.42ms(±0.244)和P32.41ms(±0.329)。峰值潜伏期与肿瘤扩展呈正相关(p<0.005)。
结论：本研究提供了有关最佳EABR性能和评估的明确说明。
结论：新的EABR分类方案依赖于在估计的后伪影阶段快速“在线”识别顶点正峰。EABR形态的可变性提供了脑干实际结构和功能状态的个体快照。
