PDF(Pubmed)
Abstract：
BACKGROUND: Preeclampsia complicated with hypofibrinogenemia is a rare disorder. We report two cases of severe preeclampsia complicated with hypofibrinogenemia followed by postpartum haemorrhage (PPH).
METHODS: Two women diagnosed as preeclampsia and hypofibrinogenemia developed severe PPH after undergoing Cesarean sections. Besides supplement with fibrinogen concentrate and supportive treatment, the second patient got administration of heparin after delivery and bleeding was stopped. The haemorrhage in case 1 didn\'t disappear until an hysterectomy. The two patients both recovered and were discharged soon.
CONCLUSIONS: Severe preeclampsia patients with hypofibrinogenemia could suffer PPH. It\'s necessary to detect and master coagulation function. Heparin could be considered to balance hypercoagulation and hypocoagulation to avoid catastrophic haemorrhage and hysterectomy.
METHODS: Two women diagnosed as preeclampsia and hypofibrinogenemia developed severe PPH after undergoing Cesarean sections. Besides supplement with fibrinogen concentrate and supportive treatment, the second patient got administration of heparin after delivery and bleeding was stopped. The haemorrhage in case 1 didn\'t disappear until an hysterectomy. The two patients both recovered and were discharged soon.
CONCLUSIONS: Severe preeclampsia patients with hypofibrinogenemia could suffer PPH. It\'s necessary to detect and master coagulation function. Heparin could be considered to balance hypercoagulation and hypocoagulation to avoid catastrophic haemorrhage and hysterectomy.
摘要：
背景：子痫前期并发低纤维蛋白原血症是一种罕见的疾病。我们报告了2例重度先兆子痫并发低纤维蛋白原血症，然后发生产后出血（PPH）。
方法：两名诊断为先兆子痫和低纤维蛋白原血症的妇女在接受剖宫产后出现严重PPH。除了补充纤维蛋白原浓缩物和支持治疗，第二例患者在分娩后接受肝素治疗,出血停止.病例1的出血直到子宫切除术后才消失。两名患者均康复并很快出院。
结论：重度子痫前期合并低纤维蛋白原血症患者可发生PPH。检测和掌握凝血功能是必要的。肝素可用于平衡高凝和低凝，以避免灾难性出血和子宫切除术。
方法：两名诊断为先兆子痫和低纤维蛋白原血症的妇女在接受剖宫产后出现严重PPH。除了补充纤维蛋白原浓缩物和支持治疗，第二例患者在分娩后接受肝素治疗,出血停止.病例1的出血直到子宫切除术后才消失。两名患者均康复并很快出院。
结论：重度子痫前期合并低纤维蛋白原血症患者可发生PPH。检测和掌握凝血功能是必要的。肝素可用于平衡高凝和低凝，以避免灾难性出血和子宫切除术。
