UNASSIGNED: Cardiac MRI exams of 118 transfusion-dependent thalassemia major patients were evaluated retrospectively. Biventricular function and volume and myocardial and liver T2* values were measured. The demographic and lab data were registered. Poisson and chi-square regression analyses investigated the correlation between the T2* value and ventricular dysfunction.
UNASSIGNED: The study participants\' mean (SD) age was 32.7y (9.02), and 47.46% were female. Forty-nine cases (41.52%) revealed at least uni-ventricular dysfunction. LV dysfunction was noted in 20 cases, whereas 47 patients revealed RV dysfunction. The risk of LV dysfunction was 5.3-fold higher in patients with cardiac T2* value less than 10msec (RR=5.3, 95% CI=1.6, 17.1, P<0.05). No association was found between age, liver T2* value, serum ferritin level, and chelation therapy with the risk of LV and RV dysfunction.
UNASSIGNED: Cardiac MRI T2* measure is a good indicator of LV dysfunction. Moreover, MRI parameters, especially RV functional measures, may have a substantial role in patient management. Therefore, cardiac MRI should be included in beta-thalassemia patients\' management strategies.
■对118例输血依赖性地中海贫血主要患者的心脏MRI检查进行回顾性评估。测量双心室功能和体积以及心肌和肝脏T2*值。登记了人口统计和实验室数据。泊松和卡方回归分析研究了T2*值与心室功能障碍之间的相关性。
■研究参与者的平均年龄(SD)为32.7y(9.02),47.46%为女性。49例(41.52%)至少显示出单心室功能障碍。20例发现LV功能障碍,而47例患者显示RV功能障碍。心脏T2*值小于10毫秒的患者发生LV功能障碍的风险为5.3倍(RR=5.3,95%CI=1.6,17.1,P<0.05)。没有发现年龄之间的关联,肝脏T2*值,血清铁蛋白水平,和螯合治疗与LV和RV功能障碍的风险。
■心脏MRIT2*测量是左心室功能障碍的良好指标。此外,MRI参数,特别是房车功能措施,可能在患者管理中发挥重要作用。因此,心脏MRI应纳入β-地中海贫血患者的管理策略。