PDF(Pubmed)
Abstract：
Oral squamous cell carcinoma (OSCC) is a complex disease with a high potential for lymph node metastasis and poor survival rates. Accurate nodal staging is crucial for prognostic assessment and treatment planning in OSCC. Recent research has suggested that nodal tumor volume (NTV) may be a more accurate indicator of nodal disease burden than traditional staging methods. However, the prognostic significance of NTV in OSCC remains unclear. This systematic review aims to evaluate the existing evidence on the relationship between NTV and prognosis in OSCC. A comprehensive search of electronic databases was conducted, and studies meeting inclusion criteria were critically appraised and synthesized. Our review identified 23 studies that investigated the prognostic significance of NTV in OSCC. The majority of studies reported that larger NTV was associated with poorer survival outcomes, although the strength of the association varied. The review also identified several areas for future research, including the standardization of NTV measurement and the integration of NTV into the broader landscape of OSCC management. In conclusion, our review suggests that NTV holds promise as a novel prognostic factor in OSCC, but more research is needed to fully elucidate its potential and inform clinical decision-making.
摘要：
口腔鳞状细胞癌（OSCC）是一种复杂的疾病，具有很高的淋巴结转移潜力和低生存率。准确的淋巴结分期对于OSCC的预后评估和治疗计划至关重要。最近的研究表明，与传统的分期方法相比，淋巴结肿瘤体积（NTV）可能是更准确的淋巴结疾病负担指标。然而,NTV在OSCC中的预后意义尚不清楚.本系统综述旨在评估OSCC中NTV与预后关系的现有证据。对电子数据库进行了全面检索,符合纳入标准的研究得到了严格的评估和综合。我们的综述确定了23项研究，调查了NTV在OSCC中的预后意义。大多数研究报告说，更大的NTV与较差的生存结果有关，尽管协会的力量各不相同。审查还确定了未来研究的几个领域，包括NTV测量的标准化以及将NTV整合到OSCC管理的更广泛领域。总之,我们的综述表明，NTV有望作为OSCC的一种新的预后因素，但需要更多的研究来充分阐明其潜力并为临床决策提供信息.
