PDF(Pubmed)
Abstract：
Phosphodiesterase-5 inhibitors (PDE5-i) have been widely used in clinical practice for the treatment of erectile dysfunction (ED). However, due to its suboptimal therapeutic effects and side effects, it is necessary to develop new medicines for ED treatment. Botanical drugs have been widely investigated as potential ED treatment drugs and have shown promising therapeutic effects. This review summarized 34 studies, including five botanical drugs with PDE5 inhibitory activity, seven botanical drugs without PDE5 inhibitory activity, and six mixed botanical drugs. The results of clinical studies regarding the aforementioned botanical drugs and relevant mechanisms are summarized in this study. It is necessary to conduct high-quality clinical trials to verify the dosage, targeted patients and therapeutic effects, and further pharmacology experiments are also needed to identify the active compounds.
摘要：
磷酸二酯酶-5抑制剂(PDE5-i)已在临床实践中广泛用于治疗勃起功能障碍(ED)。然而,由于其治疗效果和副作用欠佳，有必要开发新的治疗ED的药物。植物药物作为潜在的ED治疗药物已被广泛研究，并显示出有希望的治疗效果。这篇综述总结了34项研究，包括五种具有PDE5抑制活性的植物药，七种不含PDE5抑制活性的植物药物，和六种混合植物药。本研究总结了有关上述植物药的临床研究结果及相关机制。有必要进行高质量的临床试验来验证剂量,有针对性的患者和治疗效果，还需要进一步的药理学实验来鉴定活性化合物。
