PDF(Pubmed)
Abstract：
Gestational diabetes mellitus (GDM) increases the risks of maternal, placental, and neonatal complications. Previously, we found that a diet enriched in extra virgin olive oil (EVOO) prevents increased maternal triglyceridemia and placental proinflammatory markers in a cohort of GDM patients. The aim of this work was to evaluate maternal circulating markers of insulin resistance, placental collagen, glycogen and lipid levels, and placental levels of proteins, mRNAs, and a microRNA involved in the endocytic pathway in the same cohort of control women and women with GDM who received or did not receive a diet enriched in EVOO (36 g/day) from weeks 24 to 28 of pregnancy until term.
At term, the TG/HDL cholesterol ratio, fatty acid binding protein 4 circulating levels, and maternal BMI were increased in the GDM patients, alterations prevented by the maternal diet enriched in EVOO. Although there were no changes in placental lipid levels and lipid profile, GDM placentas were thicker than controls and showed increased glycogen and collagen content, alterations prevented by the EVOO enriched diet. GDM placentas showed increases in megalin levels, in the expression of several genes involved in the endocytic pathway, and in miR-199, which targets these genes, alterations prevented by the maternal diet enriched in EVOO.
We identified novel beneficial effects of an EVOO-enriched diet in GDM women, a diet capable of regulating maternal insulin resistance, the structure and metabolism of the placenta, and the placental endocytic pathway, suggesting effects that may be beneficial for fetal development.
At term, the TG/HDL cholesterol ratio, fatty acid binding protein 4 circulating levels, and maternal BMI were increased in the GDM patients, alterations prevented by the maternal diet enriched in EVOO. Although there were no changes in placental lipid levels and lipid profile, GDM placentas were thicker than controls and showed increased glycogen and collagen content, alterations prevented by the EVOO enriched diet. GDM placentas showed increases in megalin levels, in the expression of several genes involved in the endocytic pathway, and in miR-199, which targets these genes, alterations prevented by the maternal diet enriched in EVOO.
We identified novel beneficial effects of an EVOO-enriched diet in GDM women, a diet capable of regulating maternal insulin resistance, the structure and metabolism of the placenta, and the placental endocytic pathway, suggesting effects that may be beneficial for fetal development.
摘要：
妊娠期糖尿病（GDM）增加产妇的风险，胎盘,和新生儿并发症。以前,我们发现,在一组GDM患者中,富含特级初榨橄榄油(EVOO)的饮食可预防母体甘油三酯血症和胎盘促炎标志物的升高.这项工作的目的是评估胰岛素抵抗的母体循环标志物，胎盘胶原蛋白，糖原和脂质水平，和胎盘的蛋白质水平，mRNA,在相同的对照妇女和GDM妇女队列中，参与内吞途径的microRNA在怀孕24至28周期间接受或未接受富含EVOO（36g/天）的饮食，直至足月。
■在任期内，TG/HDL胆固醇比值，脂肪酸结合蛋白4循环水平，GDM患者的母亲BMI增加，富含EVOO的母体饮食可以预防改变。尽管胎盘脂质水平和脂质分布没有变化，GDM胎盘比对照组厚，显示糖原和胶原含量增加，EVOO丰富的饮食可以防止改变。GDM胎盘显示megalin水平增加，在参与内吞途径的几个基因的表达中，在miR-199中，靶向这些基因，富含EVOO的母体饮食可以预防改变。
■我们发现了富含EVOO的饮食对GDM女性的新的有益作用，能够调节母体胰岛素抵抗的饮食，胎盘的结构和代谢，和胎盘内吞途径，提示可能对胎儿发育有益的影响。
■在任期内，TG/HDL胆固醇比值，脂肪酸结合蛋白4循环水平，GDM患者的母亲BMI增加，富含EVOO的母体饮食可以预防改变。尽管胎盘脂质水平和脂质分布没有变化，GDM胎盘比对照组厚，显示糖原和胶原含量增加，EVOO丰富的饮食可以防止改变。GDM胎盘显示megalin水平增加，在参与内吞途径的几个基因的表达中，在miR-199中，靶向这些基因，富含EVOO的母体饮食可以预防改变。
■我们发现了富含EVOO的饮食对GDM女性的新的有益作用，能够调节母体胰岛素抵抗的饮食，胎盘的结构和代谢，和胎盘内吞途径，提示可能对胎儿发育有益的影响。
