PDF(Pubmed)
Abstract：
UNASSIGNED: Magnetic resonance imaging (MRI) is the dominant 3D imaging modality to quantify muscle properties in skeletal muscle disorders, in inherited and acquired muscle diseases, and in sarcopenia, in cachexia and frailty.
UNASSIGNED: This review covers T1 weighted and Dixon sequences, introduces T2 mapping, diffusion tensor imaging (DTI) and non-proton MRI. Technical concepts, strengths, limitations and translational aspects of these techniques are discussed in detail. Examples of clinical applications are outlined. For comparison 31P-and 13C-MR Spectroscopy are also addressed.
UNASSIGNED: MRI technology provides a rich toolset to assess muscle deterioration. In addition to classical measures such as muscle atrophy using T1 weighted imaging and fat infiltration using Dixon sequences, parameters characterizing inflammation from T2 maps, tissue sodium using non-proton MRI techniques or concentration or fiber architecture using diffusion tensor imaging may be useful for an even earlier diagnosis of the impairment of muscle quality.
UNASSIGNED: Quantitative MRI provides new options for muscle research and clinical applications. Current limitations that also impair its more widespread use in clinical trials are lack of standardization, ambiguity of image segmentation and analysis approaches, a multitude of outcome parameters without a clear strategy which ones to use and the lack of normal data.
UNASSIGNED: This review covers T1 weighted and Dixon sequences, introduces T2 mapping, diffusion tensor imaging (DTI) and non-proton MRI. Technical concepts, strengths, limitations and translational aspects of these techniques are discussed in detail. Examples of clinical applications are outlined. For comparison 31P-and 13C-MR Spectroscopy are also addressed.
UNASSIGNED: MRI technology provides a rich toolset to assess muscle deterioration. In addition to classical measures such as muscle atrophy using T1 weighted imaging and fat infiltration using Dixon sequences, parameters characterizing inflammation from T2 maps, tissue sodium using non-proton MRI techniques or concentration or fiber architecture using diffusion tensor imaging may be useful for an even earlier diagnosis of the impairment of muscle quality.
UNASSIGNED: Quantitative MRI provides new options for muscle research and clinical applications. Current limitations that also impair its more widespread use in clinical trials are lack of standardization, ambiguity of image segmentation and analysis approaches, a multitude of outcome parameters without a clear strategy which ones to use and the lack of normal data.
摘要：
■磁共振成像（MRI）是量化骨骼肌疾病中肌肉特性的主要3D成像模式，在遗传性和获得性肌肉疾病中，在肌少症中，恶病质和虚弱。
■本评论涵盖T1加权和Dixon序列，引入T2映射，扩散张量成像（DTI）和非质子MRI。技术概念,优势,详细讨论了这些技术的局限性和翻译方面。概述了临床应用的实例。为了比较,还提出了31P-和13C-MR光谱。
■MRI技术提供了丰富的工具集来评估肌肉恶化。除了经典的措施，如使用T1加权成像的肌肉萎缩和使用Dixon序列的脂肪浸润，从T2图表征炎症的参数，使用非质子MRI技术的组织钠或使用扩散张量成像的浓度或纤维结构可能有助于更早地诊断肌肉质量受损。
■定量MRI为肌肉研究和临床应用提供了新的选择。目前的局限性也削弱了其在临床试验中的更广泛使用，缺乏标准化，图像分割和分析方法的模糊性，大量的结果参数，没有一个明确的策略，哪些参数可以使用，缺乏正常的数据。
■本评论涵盖T1加权和Dixon序列，引入T2映射，扩散张量成像（DTI）和非质子MRI。技术概念,优势,详细讨论了这些技术的局限性和翻译方面。概述了临床应用的实例。为了比较,还提出了31P-和13C-MR光谱。
■MRI技术提供了丰富的工具集来评估肌肉恶化。除了经典的措施，如使用T1加权成像的肌肉萎缩和使用Dixon序列的脂肪浸润，从T2图表征炎症的参数，使用非质子MRI技术的组织钠或使用扩散张量成像的浓度或纤维结构可能有助于更早地诊断肌肉质量受损。
■定量MRI为肌肉研究和临床应用提供了新的选择。目前的局限性也削弱了其在临床试验中的更广泛使用，缺乏标准化，图像分割和分析方法的模糊性，大量的结果参数，没有一个明确的策略，哪些参数可以使用，缺乏正常的数据。
