PDF(Pubmed)
Abstract：
Malignant and potentially malignant epithelial lesions are often associated with various abnormalities such as epithelial dysplasia, abnormal DNA content, loss of heterozygosity, and chromosomal number aberrations. Screening and early detection of such abnormalities facilitates proper care and also helps to prevent further progression of potentially malignant lesions to malignancy. In such way, the presence of DNA aneuploidy in oral potentially malignant disorders (OPMDs) may serve as an indicator for the malignant transforming potential. Various assessment methods have been proposed to find the DNA ploidy status of cells. This current systematic review is mainly designed to assess the importance of ploidy status in OPMD while measuring the feasibility of using this biomarker for evaluating the hazard of malignant transformation. As an upshot of this systematic review, we can conclude that use of DNA ploidy status can serve as an independent bio-marker for predicting the malignant transformation of lesions. Furthermore, as a future scope the use of DNA ploidy analysis in normal mucosa of smokers will help to assess the malignancy risk and this technique might also help to predict the genetic predisposition of patients with malignancy.
摘要：
恶性和潜在恶性上皮病变通常与各种异常相关，如上皮发育不良，DNA含量异常,杂合性丢失，和染色体数量畸变。此类异常的筛查和早期检测有助于适当的护理，也有助于防止潜在的恶性病变进一步发展为恶性肿瘤。以这种方式,口腔潜在恶性疾病(OPMD)中DNA非整倍性的存在可以作为恶性转化潜能的指标.已经提出了各种评估方法来发现细胞的DNA倍性状态。当前的系统综述主要旨在评估OPMD中倍性状态的重要性，同时测量使用该生物标志物评估恶性转化危害的可行性。作为这次系统审查的结果，我们可以得出结论,使用DNA倍体状态可以作为预测病变恶性转化的独立生物标志物.此外，作为未来的研究范围,在吸烟者的正常粘膜中使用DNA倍体分析将有助于评估恶性肿瘤风险,该技术也可能有助于预测恶性肿瘤患者的遗传易感性.
