PDF(Pubmed)
Abstract：
Class II mandibular furcation defect is a periodontal condition characterized by a cul-de-sac lesion, a definite parallel constituent with only a portion of alveolar bone remaining intact. There may be involvement of vertical bone loss. Local drug deliveries such as Boric acid, alendronate gel, and other drugs exhibited anti-inflammatory, antibacterial & osteoblastic differentiation activity. The present systematic review compares the drugs based on their outcomes and pharmacological action. To analzse & compare various forms of local drug delivery systems on a class II furcation. A search was conducted using PubMed, Google scholar, science direct, and Pub Med central using MeSH terms - local drug delivery in periodontics, boric acid in the management of class II mandibular furcation, simvastatin in the treatment of furcation. A total of 560 articles were screened; 58 out of 560 were full-text articles accessed for eligibility, and five articles were included in the systematic review. PRISMA guidelines were used for reporting this review. In addition, five randomized controlled trials were enclosed and used in this systematic review. The various local drugs used in treating class II mandibular furcation defects are effective in the prevention of bleeding on probing, bone resorption, gingival bleeding index and increase in the bone fill, and microbial deposit removal. The managing of class II mandibular furcation defect with the drugs mentioned in this review can be effective by reducing several clinical parameters such as bleeding on probing, gingival indices, osteoblastic differentiation, bone fill, etc., Considering the results of the studies, it can be concluded that it can be used as a therapeutic therapy against class II furcation defects with positive outcomes.
摘要：
II类下颌分叉缺损是一种以盲囊病变为特征的牙周疾病，一种明确的平行成分，只有一部分牙槽骨保持完整。可能涉及垂直骨丢失。局部药物输送，如硼酸，阿仑膦酸盐凝胶，和其他药物表现出抗炎，抗菌和成骨细胞分化活性。本系统综述根据药物的结果和药理作用对药物进行了比较。分析并比较II类分叉上各种形式的局部给药系统。使用PubMed进行了搜索，谷歌学者，科学直接，和PubMed中心使用MeSH术语-牙周病中的局部药物递送，硼酸在II类下颌分叉的管理中，辛伐他汀治疗分叉。共筛选了560篇文章;560篇中的58篇是为资格而访问的全文文章,和五篇文章被纳入系统评价。PRISMA指南用于报告本综述。此外,本系统综述中使用了5项随机对照试验.用于治疗II类下颌骨分叉缺损的各种局部药物可有效预防探查出血，骨吸收，牙龈出血指数和骨填充增加，和微生物沉积物去除。使用本综述中提到的药物治疗II类下颌分叉缺损可以通过减少一些临床参数（如探查出血）而有效。牙龈指数，成骨细胞分化，骨填充,等。,考虑到研究结果，可以得出结论，它可以作为一种治疗II类分叉缺陷的治疗方法，并获得积极的结果。
