Abstract：
BACKGROUND: Cryolipolysis is a noninvasive technique for localized fat reduction, which induces selective apoptosis of the adipocytes using controlled exposure to intense cold. During the past 10 years, this technique has been shown to be safe and effective and its application has significantly increased. In this context, Cooltech® devices have been widely used around the world.
OBJECTIVE: The purpose of this retrospective study was to evaluate the efficacy and safety of the removal of localized fatty tissue in different body areas using the new Cooltech® Define controlled cooling system.
METHODS: This single-center study was carried out on 287 patients, both female and male, treated with Cooltech® Define on different body areas for a total of 1118 procedures. Follow-up evaluations were conducted to estimate efficacy and safety. Efficacy was evaluated through plicometry and photographs. Side effects were also reported.
RESULTS: Fold thickness showed a significant reduction (-69.91 ± 12.55%) after cryolipolysis treatment (fold thickness before: 35.33 ± 8.41 mm; fold thickness after: 10.69 ± 5.27 mm). Few side effects were reported, they included posttreatment pain (1.70%) and one case of paradoxical adipose hyperplasia (0.09%).
CONCLUSIONS: The Cooltech® Define cryolipolysis device is a safe, effective, and well-tolerated nonsurgical procedure for reducing localized fat.
OBJECTIVE: The purpose of this retrospective study was to evaluate the efficacy and safety of the removal of localized fatty tissue in different body areas using the new Cooltech® Define controlled cooling system.
METHODS: This single-center study was carried out on 287 patients, both female and male, treated with Cooltech® Define on different body areas for a total of 1118 procedures. Follow-up evaluations were conducted to estimate efficacy and safety. Efficacy was evaluated through plicometry and photographs. Side effects were also reported.
RESULTS: Fold thickness showed a significant reduction (-69.91 ± 12.55%) after cryolipolysis treatment (fold thickness before: 35.33 ± 8.41 mm; fold thickness after: 10.69 ± 5.27 mm). Few side effects were reported, they included posttreatment pain (1.70%) and one case of paradoxical adipose hyperplasia (0.09%).
CONCLUSIONS: The Cooltech® Define cryolipolysis device is a safe, effective, and well-tolerated nonsurgical procedure for reducing localized fat.
摘要：
背景：低温脂肪分解是一种局部脂肪减少的非侵入性技术，使用受控暴露于强烈的寒冷诱导脂肪细胞的选择性凋亡。在过去的10年里,该技术已被证明是安全有效的，其应用已大大增加。在这种情况下，Cooltech®设备已在世界各地广泛使用。
目的：这项回顾性研究的目的是评估使用新型Cooltech®Define受控冷却系统去除不同身体区域局部脂肪组织的有效性和安全性。
方法：这项单中心研究对287名患者进行，女性和男性，用Cooltech®治疗在不同的身体区域定义总共1118个程序。进行后续评估以评估疗效和安全性。通过倍率测量和照片评价功效。还报道了副作用。
结果：冷冻溶脂处理后，折叠厚度显着减少（-69.91±12.55％）（折叠前厚度：35.33±8.41mm；折叠后厚度：10.69±5.27mm）。几乎没有副作用的报道，其中包括治疗后疼痛（1.70％）和1例矛盾的脂肪增生（0.09％）。
结论：Cooltech®Define冷冻分解装置是一种安全的，有效,和耐受性良好的非手术治疗减少局部脂肪。
目的：这项回顾性研究的目的是评估使用新型Cooltech®Define受控冷却系统去除不同身体区域局部脂肪组织的有效性和安全性。
方法：这项单中心研究对287名患者进行，女性和男性，用Cooltech®治疗在不同的身体区域定义总共1118个程序。进行后续评估以评估疗效和安全性。通过倍率测量和照片评价功效。还报道了副作用。
结果：冷冻溶脂处理后，折叠厚度显着减少（-69.91±12.55％）（折叠前厚度：35.33±8.41mm；折叠后厚度：10.69±5.27mm）。几乎没有副作用的报道，其中包括治疗后疼痛（1.70％）和1例矛盾的脂肪增生（0.09％）。
结论：Cooltech®Define冷冻分解装置是一种安全的，有效,和耐受性良好的非手术治疗减少局部脂肪。
