PDF(Pubmed)
Abstract：
OBJECTIVE: Osteoarthritis is one of the most common degenerative conditions that causes pain, stiffness, and decreased functionality. The management of knee osteoarthritis necessitates collaboration among specialists from different disciplines, considering the primary clinical manifestations and functional level of the disease. The aim of this study was to highlight the disparities in postoperative outcomes between knee arthroplasty procedures with and without non-steroidal anti-inflammatory drugs (NSAIDs). The study specifically focuses on the immediate advantages and outcomes observed at the 6-month milestone.
METHODS: This study followed 713 patients who were randomly divided into two groups: a group that did not receive non-steroidal anti-inflammatory drugs (N-NSAIDs) consisting of 394 patients, and a group that received non-steroidal anti-inflammatory drugs (NSAIDs) comprising 319 patients. The study spanned a duration of 5 years (2018-2022), with patients being followed and evaluated for up to 6 months after the surgery.
RESULTS: It was observed that, from a therapeutic standpoint, the use of injectable treatments decreased. Significantly better differences were recorded in the N-NSAIDs group regarding return to pre-osteoarthritis activities at 6 months and reduced or absent night pain at 3 months (p<0.05).
CONCLUSIONS: Statistically significant improvements were observed in the N-NSAIDs group concerning the ability to resume pre-osteoarthritis activities within 6 months, as well as a reduction or absence of nighttime pain within 3 months.
METHODS: This study followed 713 patients who were randomly divided into two groups: a group that did not receive non-steroidal anti-inflammatory drugs (N-NSAIDs) consisting of 394 patients, and a group that received non-steroidal anti-inflammatory drugs (NSAIDs) comprising 319 patients. The study spanned a duration of 5 years (2018-2022), with patients being followed and evaluated for up to 6 months after the surgery.
RESULTS: It was observed that, from a therapeutic standpoint, the use of injectable treatments decreased. Significantly better differences were recorded in the N-NSAIDs group regarding return to pre-osteoarthritis activities at 6 months and reduced or absent night pain at 3 months (p<0.05).
CONCLUSIONS: Statistically significant improvements were observed in the N-NSAIDs group concerning the ability to resume pre-osteoarthritis activities within 6 months, as well as a reduction or absence of nighttime pain within 3 months.
摘要：
目的：骨关节炎是引起疼痛的最常见的退行性疾病之一，刚度,功能下降。膝骨关节炎的管理需要来自不同学科的专家之间的合作，考虑到疾病的主要临床表现和功能水平。这项研究的目的是强调使用和不使用非甾体抗炎药（NSAIDs）的膝关节置换术之间的术后结果差异。该研究特别关注在6个月里程碑观察到的直接优势和结果。
方法：这项研究追踪了713名患者，他们被随机分为两组：一组没有接受非甾体抗炎药（N-NSAIDs）的394名患者，和一组接受非甾体类抗炎药（NSAIDs）的组，包括319名患者。该研究历时5年(2018-2022年)，在手术后6个月内对患者进行随访和评估。
结果：观察到，从治疗的角度来看，注射治疗的使用减少。在N-NSAIDs组中，在6个月时恢复到骨关节炎前的活动以及在3个月时减轻或不存在夜间疼痛方面，差异显着（p<0.05）。
结论：在6个月内恢复骨关节炎前活动的能力方面，在N-NSAIDs组中观察到统计学上的显着改善，以及3个月内夜间疼痛的减轻或不存在。
方法：这项研究追踪了713名患者，他们被随机分为两组：一组没有接受非甾体抗炎药（N-NSAIDs）的394名患者，和一组接受非甾体类抗炎药（NSAIDs）的组，包括319名患者。该研究历时5年(2018-2022年)，在手术后6个月内对患者进行随访和评估。
结果：观察到，从治疗的角度来看，注射治疗的使用减少。在N-NSAIDs组中，在6个月时恢复到骨关节炎前的活动以及在3个月时减轻或不存在夜间疼痛方面，差异显着（p<0.05）。
结论：在6个月内恢复骨关节炎前活动的能力方面，在N-NSAIDs组中观察到统计学上的显着改善，以及3个月内夜间疼痛的减轻或不存在。
