Abstract：
Particle matter (PM) is a complex mixture of particles suspended in the air, mainly caused by fuel combustion from vehicles and industry, and has been related to pulmonary and cardiovascular diseases. The Metropolitan Area of Aburrá Valley in Colombia is the second most populous urban agglomeration in the country and the third densest in the world, composed of ten municipalities. Examining the physicochemical properties of PM is crucial in comprehending its composition and its effects on human health, as it varies based on the socioeconomic dynamics specific to each city. This study characterized the PM collected from the north, south, and central zones to evaluate its chemical composition and morphology. Different elements such as silicon, carbon, aluminum, potassium, calcium, sodium, iron, magnesium, and copper and the presence of unburned fuel, motor oil, and silicon fibers were identified. In vitro and in silico studies were conducted to evaluate the toxicity of the PM, and it was found that the PM collected from the central zone had the greatest impact on cell viability and caused DNA damage. The in silico study demonstrated that PM has concentration-dependent proarrhythmic effects, reflected in an action potential duration shortening and an increased number of reentries, which may contribute to the development of cardiac arrhythmias. Overall, the results suggest that the size and chemical composition of ambient PM can induce toxicity and play an important role in the generation of arrhythmias.
摘要：
颗粒物质（PM）是悬浮在空气中的颗粒的复杂混合物，主要由车辆和工业燃料燃烧引起，并与肺部和心血管疾病有关。哥伦比亚阿布拉河谷都会区是全国人口第二多、世界第三密集的城市群,由十个城市组成。检查PM的理化性质对于理解其组成及其对人体健康的影响至关重要。因为它根据每个城市特有的社会经济动态而有所不同。这项研究描述了从北方收集的PM，南,和中央区，以评估其化学成分和形态。不同的元素，如硅，碳,铝，钾，钙，钠,铁,镁，铜和未燃烧的燃料，机油,并鉴定了硅纤维。进行了体外和计算机模拟研究以评估PM的毒性，发现从中心区收集的PM对细胞活力的影响最大，并引起DNA损伤。计算机研究表明，PM具有浓度依赖性的心律失常作用，反映在动作电位持续时间的缩短和重返地球的数量增加，这可能有助于心律失常的发展。总的来说,结果表明，周围PM的大小和化学成分可以引起毒性，并在心律失常的产生中起重要作用。
