Abstract：
Maintenance and hidden/creep fluids are a major source of fluid and sodium intake in intensive care unit (ICU) patients. Recent research indicates that low versus high sodium content maintenance fluids could decrease fluid and sodium burden. We conducted a systematic review (SR) with meta-analysis to summarize the impact of maintenance fluid choice on total daily sodium in ICU patients.
Systematic literature search in Pubmed, Embase, the Cochrane Library and the.
Only controlled clinical trials were included.
trials on resuscitation fluids, performed in the emergency department only and in pediatric patients. Primary objective was the reduction in mean total sodium intake with low versus high sodium content maintenance/creep fluids.
Five studies (1105 patients) were included. Heterogeneity was high.Risk of bias was moderate. Mean daily sodium reduction was 117 mmol (95%Confidence Interval [CI] -174; -59; p < 0.001) with low versus high sodium content maintenance/creep fluids. Incidence of hyperchloremia was lower (OR 0.26; 95%CI 0.1; 0.64) with low sodium. There were no differences in the incidences of hyper-/hyponatremia and fluid balances.
Using low sodium content maintenance/creep fluids substantially reduces daily sodium burden in adult ICU patients. Significant knowledge/research gaps exist regarding relevance and safety.
PROSPERO 2022 CRD42022300577 (February 2022).
Systematic literature search in Pubmed, Embase, the Cochrane Library and the.
Only controlled clinical trials were included.
trials on resuscitation fluids, performed in the emergency department only and in pediatric patients. Primary objective was the reduction in mean total sodium intake with low versus high sodium content maintenance/creep fluids.
Five studies (1105 patients) were included. Heterogeneity was high.Risk of bias was moderate. Mean daily sodium reduction was 117 mmol (95%Confidence Interval [CI] -174; -59; p < 0.001) with low versus high sodium content maintenance/creep fluids. Incidence of hyperchloremia was lower (OR 0.26; 95%CI 0.1; 0.64) with low sodium. There were no differences in the incidences of hyper-/hyponatremia and fluid balances.
Using low sodium content maintenance/creep fluids substantially reduces daily sodium burden in adult ICU patients. Significant knowledge/research gaps exist regarding relevance and safety.
PROSPERO 2022 CRD42022300577 (February 2022).
摘要：
目的：维持和隐藏/蠕变液体是重症监护病房（ICU）患者液体和钠摄入量的主要来源。最近的研究表明，低钠含量与高钠含量的维持液可以减少液体和钠的负担。我们进行了系统评价（SR）和荟萃分析，以总结ICU患者维持液选择对每日总钠的影响。
方法：Pubmed，Embase,科克伦图书馆和.
背景：仅包括对照临床试验。
方法：关于复苏液的试验，仅在急诊科和儿科患者中进行。主要目标是减少钠含量低与高钠含量的维持/蠕变液的平均总钠摄入量。
结果：纳入5项研究（1105例患者）。异质性很高。偏倚风险适中。每日平均钠减少为117mmol(95%置信区间[CI]-174;-59;p<0.001),钠含量低与高钠维持液/蠕变液。低钠的高氯血症发生率较低（OR0.26;95CI0.1;0.64）。高/低钠血症和液体平衡的发生率没有差异。
结论：使用低钠含量的维持液/蠕动液可显著降低成人ICU患者的每日钠负荷。在相关性和安全性方面存在显著的知识/研究差距。
背景：PROSPERO2022CRD42022300577（2022年2月）。
方法：Pubmed，Embase,科克伦图书馆和.
背景：仅包括对照临床试验。
方法：关于复苏液的试验，仅在急诊科和儿科患者中进行。主要目标是减少钠含量低与高钠含量的维持/蠕变液的平均总钠摄入量。
结果：纳入5项研究（1105例患者）。异质性很高。偏倚风险适中。每日平均钠减少为117mmol(95%置信区间[CI]-174;-59;p<0.001),钠含量低与高钠维持液/蠕变液。低钠的高氯血症发生率较低（OR0.26;95CI0.1;0.64）。高/低钠血症和液体平衡的发生率没有差异。
结论：使用低钠含量的维持液/蠕动液可显著降低成人ICU患者的每日钠负荷。在相关性和安全性方面存在显著的知识/研究差距。
背景：PROSPERO2022CRD42022300577（2022年2月）。
