关键词: graft-versus-host disease secukinumab treatment

Mesh : Male Humans Child Psoriasis / drug therapy pathology Hematopoietic Stem Cell Transplantation / adverse effects Antibodies, Monoclonal, Humanized / therapeutic use Graft vs Host Disease / drug therapy pathology

来  源:   DOI:10.1111/ajd.14144

Abstract:
We describe a 9-year-old boy who developed generalised erythematous lesions 12 months after haematopoietic stem cell transplant (HSCT). Histopathology showed both features of psoriasis and graft-versus-host disease (GVHD). The lesions responded well to secukinumab, suggesting that IL-17A monoclonal antibody might be a treatment option for GVHD.
摘要:
我们描述了一个9岁的男孩,他在造血干细胞移植(HSCT)后12个月出现了全身性红斑病变。组织病理学显示银屑病和移植物抗宿主病(GVHD)的特征。病变对苏金单抗反应良好,提示IL-17A单克隆抗体可能是GVHD的治疗选择。
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