Abstract:
The human body is host to a large number of commensal microbial species such as bacteria, fungi, and viruses. Among these, the human mycobiome is often neglected as a potential cause of disease, as it is thought to be comparatively much less abundant and less diverse than the human bacteriome. Additionally, most fungi are not easily cultured, even in specific media. Hence, their study has been limited to date, mainly because of the unavailability of methods used for their detection. However, the utilization of a novel metagenomic methodology will enable the identification of well-characterized mycobiomes in several parts of the human body and broaden our knowledge of their contribution to human health and disease. In this article, we review the role of the human mycobiome in the gut, respiratory organs, skin, genital tract, and carcinogenesis, highlighting the correlations between the human mycobiome and mycobiome-associated diseases.
摘要:
人体是大量共生微生物的宿主,如细菌,真菌,和病毒。其中,人类的真菌群往往被忽略为潜在的疾病原因,因为它被认为比人类细菌组相对地少得多,多样性也少得多。此外,大多数真菌不容易培养,甚至在特定的媒体。因此,他们的研究仅限于此,主要是因为用于检测它们的方法不可用。然而,利用新的宏基因组方法将能够鉴定人体多个部位的特征明确的分枝杆菌,并扩大我们对它们对人类健康和疾病的贡献的认识。在这篇文章中,我们回顾了人类真菌在肠道中的作用,呼吸器官,皮肤,生殖道,和致癌作用,强调人类真菌群和真菌群相关疾病之间的相关性。