PDF(Pubmed)
Abstract：
The birth of ChatGPT, a cutting-edge language model-based chatbot developed by OpenAI, ushered in a new era in AI. However, due to potential pitfalls, its role in rigorous scientific research is not clear yet. This paper vividly showcases its innovative application within the field of drug discovery. Focused specifically on developing anti-cocaine addiction drugs, the study employs GPT-4 as a virtual guide, offering strategic and methodological insights to researchers working on generative models for drug candidates. The primary objective is to generate optimal drug-like molecules with desired properties. By leveraging the capabilities of ChatGPT, the study introduces a novel approach to the drug discovery process. This symbiotic partnership between AI and researchers transforms how drug development is approached. Chatbots become facilitators, steering researchers towards innovative methodologies and productive paths for creating effective drug candidates. This research sheds light on the collaborative synergy between human expertise and AI assistance, wherein ChatGPT\'s cognitive abilities enhance the design and development of potential pharmaceutical solutions. This paper not only explores the integration of advanced AI in drug discovery but also reimagines the landscape by advocating for AI-powered chatbots as trailblazers in revolutionizing therapeutic innovation.
摘要：
ChatGPT的诞生,由OpenAI开发的尖端语言模型聊天机器人，开创了人工智能的新时代，本文生动地展示了其在药物发现领域的创新应用。专注于开发抗可卡因成瘾药物，这项研究采用GPT-4作为虚拟指南，为研究人员提供战略和方法学见解，研究人员为候选药物的生成模型。主要目的是产生具有所需性质的最佳药物样分子。通过利用ChatGPT的功能，这项研究为药物发现过程引入了一种新的方法。人工智能和研究人员之间的这种共生伙伴关系改变了药物开发的方式。聊天机器人成为促进者，引导研究人员走向创新的方法和生产途径，以创造有效的候选药物。这项研究揭示了人类专业知识和人工智能辅助之间的协作协同作用，其中ChatGPT的认知能力增强了潜在药物解决方案的设计和开发。本文不仅探讨了先进AI在药物发现中的整合，而且还通过倡导AI驱动的聊天机器人作为革命性治疗创新的开拓者来重新构想这一景观。
