Abstract：
OBJECTIVE: The prognostic relevance of metabolic tumor volume (MTV) having recently been demonstrated in patients with early-stage favorable and advanced-stage Hodgkin lymphoma. The current study aimed to assess the potential prognostic value of 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in early-stage unfavorable Hodgkin lymphoma patients treated within the German Hodgkin Study Group HD17 trial.
METHODS: 18 F-FDG PET/CT images were available for MTV analysis in 154 cases. We used three different threshold methods (SUV2.5 , SUV4.0 , and SUV41% ) to calculate MTV. Receiver-operating-characteristic analysis was performed to describe the value of these parameters in predicting an adequate therapy response. Therapy response was evaluated as PET negativity after 2 cycles of eBEACOPP followed by 2 cycles of ABVD.
RESULTS: All three threshold methods analyzed for MTV showed a positive correlation with the PET response after chemotherapy. Areas under the curve (AUC) were 0.70 (95% CI 0.53-0.87) and 0.65 (0.50-0.80) using the fixed thresholds of SUV4.0 and SUV2.5 , respectively, for MTV- calculation. The calculation of MTV using a relative threshold of SUV41% showed an AUC of 0.63 (0.47-0.79).
CONCLUSIONS: MTV does have predictive value after chemotherapy in early-stage unfavorable Hodgkin lymphoma, particularly when the fixed threshold of SUV4.0 is used for MTV calculation.
BACKGROUND: ClinicalTrials.gov NCT01356680.
METHODS: 18 F-FDG PET/CT images were available for MTV analysis in 154 cases. We used three different threshold methods (SUV2.5 , SUV4.0 , and SUV41% ) to calculate MTV. Receiver-operating-characteristic analysis was performed to describe the value of these parameters in predicting an adequate therapy response. Therapy response was evaluated as PET negativity after 2 cycles of eBEACOPP followed by 2 cycles of ABVD.
RESULTS: All three threshold methods analyzed for MTV showed a positive correlation with the PET response after chemotherapy. Areas under the curve (AUC) were 0.70 (95% CI 0.53-0.87) and 0.65 (0.50-0.80) using the fixed thresholds of SUV4.0 and SUV2.5 , respectively, for MTV- calculation. The calculation of MTV using a relative threshold of SUV41% showed an AUC of 0.63 (0.47-0.79).
CONCLUSIONS: MTV does have predictive value after chemotherapy in early-stage unfavorable Hodgkin lymphoma, particularly when the fixed threshold of SUV4.0 is used for MTV calculation.
BACKGROUND: ClinicalTrials.gov NCT01356680.
摘要：
目的：最近在早期有利和晚期霍奇金淋巴瘤患者中证实了代谢性肿瘤体积（MTV）的预后相关性。本研究旨在评估18F-氟代脱氧葡萄糖（FDG）正电子发射断层扫描（PET）在德国霍奇金研究组HD17试验中治疗的早期不良霍奇金淋巴瘤患者中的潜在预后价值。
方法：对154例患者进行MTV分析，得到18F-FDGPET/CT图像。我们使用了三种不同的阈值方法(SUV2.5，SUV4.0,和SUV41%)来计算MTV。进行接收器操作特性分析以描述这些参数在预测适当治疗反应中的值。在2个周期的eBEACOPP和2个周期的ABVD后，将治疗反应评估为PET阴性。
结果：分析MTV的所有三种阈值方法均显示与化疗后的PET反应呈正相关。使用SUV4.0和SUV2.5的固定阈值，曲线下面积（AUC）为0.70（95％CI0.53-0.87）和0.65（0.50-0.80），分别,用于MTV计算。使用相对阈值SUV41%计算MTV显示AUC为0.63(0.47-0.79)。
结论：MTV在早期不良霍奇金淋巴瘤化疗后确实具有预测价值，特别是当SUV4.0的固定阈值用于MTV计算时。
背景：ClinicalTrials.govNCT01356680。
方法：对154例患者进行MTV分析，得到18F-FDGPET/CT图像。我们使用了三种不同的阈值方法(SUV2.5，SUV4.0,和SUV41%)来计算MTV。进行接收器操作特性分析以描述这些参数在预测适当治疗反应中的值。在2个周期的eBEACOPP和2个周期的ABVD后，将治疗反应评估为PET阴性。
结果：分析MTV的所有三种阈值方法均显示与化疗后的PET反应呈正相关。使用SUV4.0和SUV2.5的固定阈值，曲线下面积（AUC）为0.70（95％CI0.53-0.87）和0.65（0.50-0.80），分别,用于MTV计算。使用相对阈值SUV41%计算MTV显示AUC为0.63(0.47-0.79)。
结论：MTV在早期不良霍奇金淋巴瘤化疗后确实具有预测价值，特别是当SUV4.0的固定阈值用于MTV计算时。
背景：ClinicalTrials.govNCT01356680。
